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The role of acid sensing nociceptors in the development of cancer-induced bone pain

Research Project

Project/Area Number 22791811
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionOsaka Medical College (2011)
Osaka University (2010)

Principal Investigator

NAKANISHI Masako  大阪医科大学, 医学部, 助教 (60437382)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords骨転移 / 癌性疼痛 / 酸感受性受容体 / 動物モデル
Research Abstract

The pH-sensitive fluorescence dye indicated that acidic microenvironment was created in bone metastases of rats. It was suggested that acidic microenvironment activate acid sensing nociceptors in the sensory neurons, which in turn leads to up-regulation of CGRP expression. These events may be involved in the pathophysiology of bone pain.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (16 results)

All 2012 2011 2010

All Journal Article (7 results) (of which Peer Reviewed: 1 results) Presentation (9 results)

  • [Journal Article] The a3 isoform vacuolar type H+-ATPase promotes distant metastasis in the mouse B16 melanoma cells2011

    • Author(s)
      Nishisho T, Hata K, Nakanishi M, Morita Y, Sun-Wada H, Wada Y, Yasui N, Yoneda T
    • Journal Title

      Mol Cancer Res

      Volume: 9 Pages: 845-855

    • Related Report
      2011 Final Research Report
  • [Journal Article] Encounter of cancer cells with bone. Molecular mechanism of cancer-induced bone pain2011

    • Author(s)
      Nakanishi M, Hata K, Yoneda T
    • Journal Title

      Clin Calcium

      Volume: 21 Pages: 357-362

    • Related Report
      2011 Final Research Report
  • [Journal Article] Encounter of cancer cells with bone. The bone microenvironment and cancer metastasis2011

    • Author(s)
      Hata K, Nakanishi M, Morita Y, Yoneda T
    • Journal Title

      Clin Calcium

      Volume: 21 Pages: 329-355

    • Related Report
      2011 Final Research Report
  • [Journal Article] Involvement of acidic microenvironment in the pathophysiology of cancer-associated bone pain2011

    • Author(s)
      Yoneda T, Hata K, Nakanishi M, Nagae M, Nagayama T, Wakabayashi H, Nishisho T, Sakurai T and Hiraga T
    • Journal Title

      Bone

      Volume: 48 Pages: 100-105

    • Related Report
      2011 Final Research Report
  • [Journal Article] 骨転移に伴うがん性骨痛の分子メカニズム2011

    • Author(s)
      中西雅子、波多賢二、米田俊之
    • Journal Title

      CLINICAL CALCIUM

      Volume: 21 Pages: 357-363

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Acid activation of Trpv1 leads to an up-regulation of calcitonin gene related peptide expression in dorsal root ganglion neurons via the CaMK-CREB cascade : A potential mechanism of inflammatory pain2010

    • Author(s)
      Nakanishi M, Hata K, Nagayama T, Sakurai T, Nishisho T, Wakabayashi H, Hiraga T, Ebisu S and Yoneda T
    • Journal Title

      Mol. Biol. Cell

      Volume: 21 Pages: 2568-2577

    • Related Report
      2011 Final Research Report
  • [Journal Article] Acid activation of Trpv1 leads to an up-regulation of CGRP expression in DRG neurons via the CaMK-CREB cascade : a potential mechanism of inflammatory pain.2010

    • Author(s)
      Masako Nakanishi
    • Journal Title

      Mol Biol Cell

      Volume: 21 Pages: 2568-2577

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Involvement of acidic microenvironment on the cancer-induced bone pain2012

    • Author(s)
      Masako Nakanishi, Kenji Hata, Toshiyuki Yoneda
    • Organizer
      第117回日本解剖学会
    • Place of Presentation
      甲府
    • Year and Date
      2012-03-28
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Up-regulation of CGRP expression by acid-activated calcium channel nociceptor Trpv1 is involved in bone pain2011

    • Author(s)
      中西雅子、波多賢二、永山智崇、西庄俊彦、米田俊之
    • Organizer
      第5回Bone Research Seminar
    • Place of Presentation
      東京
    • Year and Date
      2011-02-19
    • Related Report
      2011 Final Research Report
  • [Presentation] Up-regulation of CGRP expression by acid-activated calcium channel nociceptor Trpv1 is involved in bone pain.2011

    • Author(s)
      中西雅子
    • Organizer
      第5回Bone Research Seminar
    • Place of Presentation
      東京コンファレンスセンター(招待講演)
    • Year and Date
      2011-02-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] Up-regulation of CGRP expression by acid-activated calcium channel nociceptor Trpv1 is involved in bone pain2010

    • Author(s)
      Masako Nakanishi, Kenji Hata, Tomotaka Nagayama, Toshihiko Nishisho, Toshiyuki Yoneda
    • Organizer
      The American Society for Bone and Mineral Research 2010 Annual Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2010-10-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Up-regulation of CGRP expression by acid-activated calcium channel nociceptor Trpv1 is involved in bone pain.2010

    • Author(s)
      Masako Nakanishi
    • Organizer
      The American Society for Bone and Mineral Research 2010 Annual Meeting
    • Place of Presentation
      Metro Toronto Convention Center(Canada)
    • Year and Date
      2010-10-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨転移巣の酸性環境はTRPV1の活性化によるCGRPの発現増加を介して疼痛に関与する2010

    • Author(s)
      中西雅子、米田俊之
    • Organizer
      第69回日本癌学会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Acid microenvironment in bone metastases is involved in pain signal through CGRP regulation following Trpv1 activation.2010

    • Author(s)
      Masako Nakanishi
    • Organizer
      第69回日本癌学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨転移巣の酸性環境は知覚神経TRPV1の活性化によるCGRPの発現増加を介して疼痛を誘発する2010

    • Author(s)
      中西雅子、波多賢二、西庄俊彦、米田俊之
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-23
    • Related Report
      2011 Final Research Report
  • [Presentation] 骨転移巣の酸性環境は知覚神経TRPV1の活性化によるCGRPの発現増加を介して疼痛を誘発する2010

    • Author(s)
      中西雅子
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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