Elucidation of association and the mechanism of oral bacteria in the circulatory disease
| Project/Area Number |
22791814
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 免疫 / 感染 / 炎症 / 口腔細菌 / 感染性心内膜炎 / 大動脈瘤 / 細菌 / PCR |
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| Research Abstract |
We obtained dental plaque specimens from the patient who underwent heart valve replacement or removal of aortic aneurysms in Wakayama Medical University. In addition, we collected aortic valve specimens and aortic aneurysmal wall specimens from the same group of patients. Bacterial DNA was extracted from both cardiovascular tissues and dental plaque in those cases. Then, species-specific real-time polymerase chain reaction assays were used to analyze the occurrences of periodontal bacterial species. A streptococcus mutans was the most frequently detected species in the cardiovascular specimens. However our results showed no association between oral bacterial species and bacteria in cardiovascular diseases.
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Report
(3 results)
Research Products
(1 results)
