Elucidation of mechanism for induction of intestinal mucosal immune response to develop effective oral vaccine
| Project/Area Number |
22791816
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 腸管粘膜免疫 / 分泌型IgA / サルモネラ / パイエル板 / 経口投与型ワクチン / Salmonella / FTY-720 / CCR7 / 樹状細胞 / 腸管膜リンパ節 |
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| Research Abstract |
Cell transfer experiments showed that PP, but not SP-cell transferred mice could elicit the Ag-specific intestinal IgA immunity against orally administered rSalmonella. Further, antigen priming solely occurred in PP induces Ag-specific intestinal IgA immunity. On the other hand, CCR7 signaling which is important for dendritic cell migration may not be essential for induction of Ag-specific intestinal IgA immunity.
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Report
(3 results)
Research Products
(2 results)
