| Project/Area Number |
22791820
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
AZUMA Naoto 兵庫医科大学, 医学部, 助教 (10461039)
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| Research Collaborator |
KATADA Yoshinori 国立病院機構大阪南医療センター, アレルギー科, 医長
KANDA Chieri 兵庫医科大学, 医学部, 大学院生
KITANO Sachie 兵庫医科大学, 医学部, 実験助手
NISHIOKA Aki 兵庫医科大学, 医学部, 医員 (90412030)
SEKIGUCHI Masahiro 兵庫医科大学, 医学部, 助教 (50528958)
KITANO Masayasu 兵庫医科大学, 医学部, 助教 (00412031)
MATSUI Kiyoshi 兵庫医科大学, 医学部, 非常勤医師 (00291815)
SANO Hajime 兵庫医科大学, 医学部, 主任教授 (00196304)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 免疫・感染・炎症 / シェーグレン症候群 / 唾液中EGF / 口腔内病変 |
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| Research Abstract |
Salivary epidermal growth factor(EGF) plays a role in healing of damaged oral mucosa. However, the kinetics of salivary EGF in Sjogren's Syndrome(SS) is not well-documented. The objective of this study was to assess changes in salivary EGF and the correlation between salivary EGF and the severity of oral manifestations in patients with SS. Consequently, in SS, not only saliva volume but salivary EGF output remain reduced throughout. Lower salivary EGF level is impairments of the saliva quality associate with recurrent oral manifestations.
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