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Search of evidence on the effect with dental resin curing light irradiation against dental pulp

Research Project

Project/Area Number 22791848
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionKanagawa Dental College

Principal Investigator

YOSHINO Fumihiko  神奈川歯科大学, 歯学部, 准教授 (20308307)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords光照射器 / 活性酸素 / 青色光 / 酸化ストレス / アポトーシス / レジン光照射器 / 活性酸素種 / 抗酸化剤 / ハロゲン光 / 歯科用可視光照射器 / 血管収縮 / ノルアドレナリン / 一重項酸素 / ヒドロキシルラジカル / スーパーオキシド
Research Abstract

Dental resin curing light has been used to restore of tooth with resin-based composite fillings and to treat of tooth bleaching. However, it has not been less considered the effect on the oral tissues such as dental pulp or oral mucosa. The aim of this study was to investigate whether dental resin curing light irradiation is affected on the dental pulp. We found that irradiation of resin curing blue light was increased the level of lipid peroxidation on isolated rat aorta blood vessels to use the measurement of malondialdehyde. Furthermore, it was decreased the cell proliferation activity in time-dependent manner and was induced the apoptosis of human aorta vascular smooth muscle cells(VSMC). Therefore, these results indicated that reactive oxygen species such as hydrogen peroxide and hydroxyl radical were generated in VSMC by blue light irradiation, and they were induced the cytotoxicity associated with oxidative stress which was increased the lipid peroxidation and apoptosis. In addition, N-acetyl-L-cysteine which is typical intracellular antioxidants prevented VSMC from cytotoxicity associated with oxidative stress.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2012 2011 2010 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (9 results) Remarks (1 results)

  • [Journal Article] Crocetin reduces the oxidative stress induced reactive oxygen species in the SHRSPs brain2011

    • Author(s)
      Yoshino F., Yoshida A., Umigai N., Kubo K., Lee M-C.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 49(3) Pages: 182-187

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Soft-food diet induces oxidative stress in the rat brain2011

    • Author(s)
      Ohno A., Yoshino F., Yoshida A., Hori N., Ono Y., Kimoto K., Onozuka M., Lee M-C.
    • Journal Title

      Neuroscience Letters

      Volume: 508 Pages: 42-46

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crocetin reduces the oxidative stress induced reactive oxygen species in the stroke-prone spontaneously hypertensive rats (SHRSPs) brain2011

    • Author(s)
      Yoshino F, Yoshida A., Umigai N., Kubo K., Lee M-C.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 49 Issue: 3 Pages: 182-187

    • DOI

      10.3164/jcbn.11-01

    • NAID

      130004466653

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of Anti-Aging Effects of Fish Products Peptide in Middle-Aged Subjects2011

    • Author(s)
      Yoshino F., Yoshida A., Sugiyama S., Tokutomi F., Miyamoto C., Maehata Y., Kobayashi K., Wada-Takahashi S., Maetani T., Okada E., Okada Y., Komatsu T., Takahashi S-S., Wan J., Lee M-C.
    • Journal Title

      Anti-Aging Medicine

      Volume: 8 Pages: 48-52

    • NAID

      130000968342

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct Assessment of the Antioxidant Properties of Midazolam by Electron Spin Resonance Spectroscopy2011

    • Author(s)
      Hata M., Kobayashi K., Yoshino F., Yoshida A., Sugiyama S., Miyamoto C., Tokutomi F., Maehata Y., Wada-Takahashi S., Takahashi S-S., Komatsu T., Yoshida K., Lee M-C.
    • Journal Title

      Journal of Anesthesia

      Volume: 25 Issue: 5 Pages: 765-769

    • DOI

      10.1007/s00540-011-1184-6

    • NAID

      10031137045

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct assessment by electron spin resonance spectroscopy of the antioxidant effects of French maritime pine bark extract in the maxillofacial region of hairless mice2011

    • Author(s)
      Yoshida A., Yoshino F., Tsubata M., Ikeguchi M., Nakamura T., Lee M-C.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 49 Issue: 2 Pages: 79-86

    • DOI

      10.3164/jcbn.10-103

    • NAID

      130004466650

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct Assessments of the Antioxidant Effects of the Novel Collagen Peptide on Reactive Oxygen Species Using Electron Spin Resonance Spectroscopy2011

    • Author(s)
      Kobayashi K., Maehata Y., Kawamura Y., Kusubata M., Hattori S., Tanaka K., Miyamoto C., Yoshino F., Yoshida A., Wada-Takahashi S., Komatsu T., Takahashi S-S., Lee M-C.
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 116 Issue: 1 Pages: 97-106

    • DOI

      10.1254/jphs.10321FP

    • NAID

      10029894130

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electrostatic control of protein adsorption on UV-photofunctionalized titanium.2010

    • Author(s)
      Hori N, Ueno T, Minamikawa H, Iwasa F, Yoshino F, Kimoto K, Lee MC, Ogawa T
    • Journal Title

      Acta Biomateial

      Volume: 6 Pages: 4175-4180

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reactive Oxygen Species (ROS) Reduce the Expression of BRAK/CXCL14in Human Head and Neck Squamous Cell Carcinoma Cells.2010

    • Author(s)
      Maehata Y, Ozawa S, Kobayashi K, Kato Y, Yoshino F, Miyamoto C, Izukuri K, Kubota E, Hata R-I, Lee M-C
    • Journal Title

      Free Radical Research

      Volume: 44 Pages: 913-924

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ESR detection of ROS generated by TiO2 coated with fluoridated apatite.2010

    • Author(s)
      Sawada T, Yoshino F, Kimoto K, Takahashi Y, Shibata T, Hamada N, Sawada T, Toyoda M, Lee M-C
    • Journal Title

      Journal of Dental Research

      Volume: 89 Pages: 848-853

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Assessments of salivary antioxidant activity using electron spin resonance spectroscopy

    • Author(s)
      Yoshino F., Yoshida A., Wada-Takahashi S., Sugiyama S., Tokutomi F., Maehata Y., Miyamoto C., Komatsu T., Takahashi SS., Kobayashi K., Lee M-C.
    • Journal Title

      Archives of Oral Biology

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 歯科用レジン照射器の青色光が血管平滑筋へ及ぼす影響の検討2012

    • Author(s)
      吉田彩佳, 吉野文彦, 前畑洋次郎, 高橋俊介, 高橋聡子, 小林杏, 宮本千央, 徳富文彬, 李昌一
    • Organizer
      神奈川歯科大学学会第137回例会
    • Place of Presentation
      神奈川歯科大学(横須賀)
    • Year and Date
      2012-01-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 歯科用レジン照射器の青色光が血管平滑筋へ及ぼす影響の検討2012

    • Author(s)
      吉田彩佳, 吉野文彦, 前畑洋次郎, 高橋俊介, 高橋聡子, 小林杏, 宮本千央, 徳富文彬, 李昌一
    • Organizer
      神奈川歯科大学学会第137回例会
    • Place of Presentation
      横須賀
    • Related Report
      2011 Final Research Report
  • [Presentation] 歯科用可視光線照射器による光照射の血管平滑筋に対する影響2011

    • Author(s)
      吉野文彦, 吉田彩佳, 西村知子, 石井信之, 李昌一
    • Organizer
      第135回日本歯科保存学会秋季大会
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 歯科用可視光線照射器による光照射の血管平滑筋に対する影響2011

    • Author(s)
      吉野文彦, 吉田彩佳, 西村知子, 石井信之, 李昌一
    • Organizer
      第135回日本歯科保存学会2011年度秋季学術大会
    • Place of Presentation
      大阪国際交流センター(大阪)
    • Year and Date
      2011-10-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 歯周疾患に関わる酸化ストレスとサプリメンテーションによる予防効果2011

    • Author(s)
      吉野文彦
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2011-05-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規コラーゲンペプチドは紫外線照射によって引き起こされる細胞障害を抑制する2011

    • Author(s)
      小林杏, 前畑洋次郎, 宮本千央, 徳富文彬, 杉山秀太, 吉田彩佳, 吉野文彦, 高橋聡子, 前谷崇志, 川村陽介, 辻村傑, 岡田永三, 岡田康江, 西村成文, 小松知子, 高橋俊介, 李昌一
    • Organizer
      第11回日本抗加齢医学会総会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2011-05-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] アンチエイジングサプリメントの抗酸化能評価~電子スピン共鳴(ESR)法による~2010

    • Author(s)
      吉野文彦
    • Organizer
      食品開発展2010
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2010-10-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] アンチエイジングサプリメントの抗酸化能評価と臨床評価の実際2010

    • Author(s)
      吉野文彦
    • Organizer
      第10回国際バイオEXPO
    • Place of Presentation
      東京国際フォーラム(東京)
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 二酸化チタン光触媒を応用した新規歯牙漂白剤の開発2010

    • Author(s)
      吉野文彦
    • Organizer
      第63回日本酸化ストレス学会学術集会
    • Place of Presentation
      横浜県民センター(神奈川)
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.kdcnet.ac.jp/college/medicine/yakuri/yakuri.htm

    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-06-06  

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