Effects of mechanical stress on the differentiation into hard tissue formation cells from dental pulp cells

• Project/Area Number: 22791851
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Conservative dentistry
• Research Institution: Tsurumi University
• Principal Investigator: SHIRAKAWA Satoshi 鶴見大学, 歯学部, 助教 (50460176)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 歯内療法学 / メカニカルストレス

Research Abstract

The alkaline phosphatase activity, that shows the differentiation into hard tissue formation cells, on RPC-C2A cells was suppressed by mechanical stress. Also, alkaline phosphatase activity on human dental pulp cells was similarly suppressed by mechanical stress. These results show mechanical stress may suppress hard tissue formation cell.