Development of dentin-pulp complex regeneration therapy by three typesof stem cells
| Project/Area Number |
22791853
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Conservative dentistry
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| Research Institution | Aichi Gakuin University |
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Principal Investigator |
OZEKI Nobuaki 愛知学院大学, 歯学部, 講師 (70469005)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 歯内療法学 / 骨格筋幹細胞 / ES 細胞 / iPS 細胞 / 象牙芽細胞 / 体性幹細胞 / 胚性幹細胞 / 人工多能性幹細胞 / 象牙質・歯髄複合体 |
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| Research Abstract |
We have examined the mechanism of three types of stem cells differentiation to odontoblasts for the purpose of dentin regeneration. Morphological analysis indicated that retinoic acid and BMP-4 induced differentiation to the odontogenic pathway. Differentiated cells showed markers of odontoblast differentiation. Moreover, we found significant integrin α2β1 and αVβ3 expression with increased adhesion and motility on laminin-1 and collagen type-I substrates.
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Report
(4 results)
Research Products
(10 results)
