| Project/Area Number |
22791868
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NOZAKI Kosuke 東京医科歯科大学, 生体材料工学研究所, 特任助教 (00507767)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 繰り返し荷重 / 歯周組織 / 破骨細胞 / メカニカルストレス / 歯根膜 / in vivo / 組織切片 / 免疫染色 |
|---|
| Research Abstract |
It is well accepted that cyclic mechanical loading induces osteoclastogenesis in periodental tissue, but its molecular mechanisms are not well understood, in part because of a lack of appropriate models. In this study, we investigated a novel device that allows cyclic mechanical loading to be performed in a well controlled manner. Furthermore, by employing this model, the effects of cyclic loading on osteoclast recruitment in the periodontal tissue were described. Osteoclastogenesis was induced within a alveolar bone subjected to a compression force. With large mechanical stress, cells that were positive for tartrate-resistant acid phosphate, receptor activator of nuclear factor-kB ligand and osteoprotegerin were significantly increased in the alveolar bone. By using this device, osteoclast recruitment in the periodontal tissues were observed with excessive loadings.
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