Development and Evaluation of Novel Bone Augmentation Strategy through Cellular Engineering Using Epigenetic Regulation
| Project/Area Number |
22791873
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
AKIBA Yosuke 新潟大学, 医歯学系, 助教 (70547512)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | エピジェネティクス / 骨造成 / HDACI / 骨再生医療 / 再生医学 / 歯学 / 細胞・組織 / 発生・分化 / 生体材料 |
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| Research Abstract |
Histone deacetylase inhibitor(HDACI) increases transcriptional activity through chromatin remodeling regulation. In this study, we investigated the possibility and mechanism of bone augmentation mediated by osteogenic cells treated with HDACI and systematic administration effect of HDACI on bone metabolism.
HDACI treated cells showed higher mineralization ability than control. HDACI administration induced faster bone formation and bone defect healing.
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Report
(3 results)
Research Products
(19 results)
