Development of an osteogenesis-inducible material using possible inflammation control of SVVYGLR functional peptide

• Project/Area Number: 22791882
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Osaka University
• Principal Investigator: KANEDA Yoshitoshi 大阪大学, 歯学部附属病院, 医員 (70448124)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 歯科補綴学一般 / SVVYGLR / 骨芽細胞 / 破骨細 / 炎症 / 破骨細胞 / 骨組織再生 / インテグリン

Research Abstract

Effects of the functional peptide SVVYGLR on osteoblasts and osteoclasts during bone regeneration was investigated aiming at development of an osteogenesis-inducible peptide material by its possible inflammation control. The synthetic SVVYGLR peptide(1-10μg/ site) did not show apparent anti-inflammatory effects on the rat calvaria bone regeneration and on the implant osseointegration in the rat femurs. On the other hand, significant inhibitory effects of the peptide on osteoclast activities during bone regeneration were revealed