The Relationship between Sleep Bruxism and Peripheral-type Benzoidiazepine Receptor Gene Polymorphism

• Project/Area Number: 22791898
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Fukuoka Dental College (2011); Kyushu Dental College (2010)
• Principal Investigator: MAKINO Michiko 福岡歯科大学, 歯学部, 助教 (50550729)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: ブラシキズム / ストレス / 遺伝子多型 / ブラキシズム / 遺伝子 / 唾液 / PBR

Research Abstract

The objective of this study is to clarify the relationship between sleep bruxism behavior and Chromogranin A(CgA) level in saliva and Peripheral-type Benzodiazepine Receptor(PBR) gene polymorphism. We used small electromyographic monitors for measuring sleep bruxism. We measured the concentration of CgA in saliva as a stress biomarker. We analyzed PBR gene and administered the StateTrait Anxiety Inventory(STAI) to the subjects. The groups of the polymorphism of the PBR gene were significantly correlated with the number of bruxism event. We suggested that the subjects of the polymorphism PBR gene might have a higher risk of Sleep bruxism.

Research Products

• [Presentation] ナイトガード装着が睡眠前後における精神的ストレスに与える影響 (2011)
  • Author(s): 高橋英敬, 正木千尋, 柄慎太郎, 友枝圭, 近藤祐介, 丸山俊正, 牧野路子, 吉田政樹, 中本哲自, 細川龍司
  • Organizer: 23年度日本補綴歯科学会九州支部学術大会
  • Place of Presentation: 長崎
  • Year and Date: 2011-11-06
• [Presentation] Association of Peripheral-type Benzodiazepine Receptor gene polymorphism with Sleep Bruxism (2011)
  • Author(s): T. Murakami, C. Masaki, H. Takahashi, M. Makino, T. Nakamoto, R. Hosokawa
  • Organizer: 第59回Japanese Association for Dental Research学術大会
  • Place of Presentation: 広島
  • Year and Date: 2011-10-08
• [Presentation] 末梢型ベンゾジアゼピン受容体(PBR)遺伝子多型と睡眠時ブラキシズムとの関連について (2011)
  • Author(s): 村上貴也, 正木千尋, 高橋英敬, 牧野路子, 中本哲自, 細川隆司
  • Organizer: 第71回九州歯科学会
  • Place of Presentation: 福岡
  • Year and Date: 2011-05-29
• [Presentation] 末梢型ベンゾジアゼピン受容体(PBR)遺伝子多型と睡眠時ブラキシズムの関連について (2011)
  • Author(s): 村上貴也
  • Organizer: 第71回九州歯科学会総会
  • Place of Presentation: 北九州
• [Presentation] Association of Peripheral-type Benzodiazepine Receptor gene Polymorphism with Sleep Bruxism (2011)
  • Author(s): T.Murakami
  • Organizer: 第59回JADR学術大会
  • Place of Presentation: 広島
• [Presentation] ナイトガード装着が睡眠前後における精神的ストレスに与える影響 (2011)
  • Author(s): 高橋英敬
  • Organizer: 平成23年度日本補綴歯科学会九州支部学術大会
  • Place of Presentation: 長崎
• [Presentation] Risk Factors of the Immediate-Loaded Implants : Five Years Retrospective Study (2010)
  • Author(s): M.MAKINO, C.MASAKI, A.TAKAHASHI, K.KIMURA, T.NAKAMOTO, R.HOSOKAWA
  • Organizer: IADR/AADR 88th General Session
  • Place of Presentation: Barcelona, Spain