Effect of dental pulp stem cell therapy for cerebral ischemia

• Project/Area Number: 22791899
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Health Sciences University of Hokkaido
• Principal Investigator: TOYOSHITA Yoshifumi 北海道医療大学, 歯学部, 講師 (20399900)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 脳梗塞 / 歯髄 / 神経幹細胞 / 分化 / 細胞移植 / 再生治療 / 脳梗塞モデルラット

Research Abstract

Rat dental pulpcells were differentiated into neural stem cells and these cells were trancplanted to rat middle cerebral artery occlusion models. The therapeutic transplantation promotes recovery of the disorders after cerebral infarction.

Research Products

• [Journal Article] The correlation among practical training components in preclinical training of complete denture prosthodontics (2013)
  • Author(s): Yoshifumi Toyoshita 、 Satoshi Nuka 、Kastuya Kawanishi、 Mai Kono、 Hideki Aita、Hisashi Koshino
  • Journal Title: 北海道医療大学歯学会雑誌 Volume: (印刷中)
  • NAID: 120005456723
  • Peer Reviewed
• [Journal Article] The correlation among practical training components in preclinical training of complete denture prosthodontics (2013)
  • Author(s): Yoshifumi Toyoshita
  • Journal Title: 北海道医療大学歯学会雑誌 Volume: 32
  • NAID: 120005456723
  • Peer Reviewed
• [Journal Article] 東日本大震災の被災地における歯科医療支援活動と栄養・食生活支援活動との関連について (2012)
  • Author(s): 川西克弥、 豊下祥史、越野 寿、河野 舞、松原国男、会田康史、會田英紀、池田和博、守屋信吾、三浦宏子
  • Journal Title: 日本咀嚼学会雑誌 Volume: 22巻 Pages: 52-61
  • Peer Reviewed
• [Journal Article] 定高齢者候補者の咀嚼機能と基本チェックリストの各因子との相関 (2012)
  • Author(s): 豊下祥史、会田康史、額 諭史、川西克弥、會田英紀、池田和博、守屋信吾、越野 寿
  • Journal Title: 日本補綴歯科学会誌 Volume: 4巻 Pages: 49-58
  • Peer Reviewed
• [Journal Article] 東日本大震災の被災地における歯科医療支援活動と栄養・食生活支援活動との関連について (2012)
  • Author(s): 川西克弥
  • Journal Title: 日本咀嚼学会雑誌 Volume: 22 Pages: 52-61
  • Peer Reviewed
• [Journal Article] Relationship between periodontal status and intellectual function among community-dwelling elderly persons (2011)
  • Author(s): Shingo Moriya, Kanchu Tei, Yoshifumi Toyoshita, Hisashi Koshino, Nobuo Inoue, Hiroko Miura
  • Journal Title: Gerodontology Volume: (in press) Issue: 2
  • DOI: 10.1111/j.1741-2358.2011.00483.x
  • Peer Reviewed
• [Journal Article] Occlusal-masticatory function and learning and memory-Immunohistochemical, biochemical, behavioral and electrophysiological studies in rats- (2011)
  • Author(s): Toshihiro Hirai, Youngnam Kang, Hisashi Koshino, Katsuya Kawanishi, Yoshifumi Toyoshita, Yasuhiro Ikeda, Mitsuru Saito
  • Journal Title: Japanese Dental Science Review Volume: 46 Pages: 143-149
  • NAID: 10026519008
  • Peer Reviewed
• [Journal Article] Occlusal-masticatory function and learning and memory -Immunohistochemical, biochemical, behavioral and electrophysiological studies in rats - (2010)
  • Author(s): Toshihiro Hirai、Youngnam Kang、Hisashi Koshino 、Katsuya Kawanishi 、 Yoshifumi Toyoshita、 Yasuhiro Ikeda、 Mitsuru Saito
  • Journal Title: Japanese Dental Science Review Volume: 46巻 Pages: 143-149
  • NAID: 10026519008
  • URL: http://dx.doi.org/10.1016/j.jdsr.2009.12.002
  • Peer Reviewed
• [Journal Article] Effect of Mastication after Middle Cerebral Artery Occlusion in Rats (2010)
  • Author(s): Katsuya Kawanishi 、 Hisashi Koshino 、Yoshifumi Toyoshita 、 Maki Tanaka 、Toshihiro Hirai
  • Journal Title: Journal of Stroke andCerebrovascular Diseases Volume: 19巻 Issue: 5 Pages: 398-403
  • DOI: 10.1016/j.jstrokecerebrovasdis.2009.07.011
  • Peer Reviewed
• [Presentation] Potential for differentiation of dental pulp cells into neuron (2013)
  • Author(s): Toyoshita Yoshifumi、Kawanishi Katsuya、Sasaki Mizuho 、 Aita Hideki 、 Koshino Hisashi
  • Organizer: 91th General Session & Exhibition of the IADR
  • Place of Presentation: アメリカ合衆国シアトル
  • Year and Date: 2013-03-23
• [Presentation] 脳梗塞モデルラットの脳内における細胞増殖への咀嚼の影響 (2012)
  • Author(s): 佐々木みづほ、川西克弥、豊下祥史、會田英紀、越野 寿
  • Organizer: 日本咀嚼学会第23回総会・学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2012-10-14
• [Presentation] 脳梗塞モデルラットにおける海馬歯状回の細胞増殖への咀嚼の影響 (2012)
  • Author(s): 佐々木みづほ、川西克弥、豊下祥史、會田英紀、越野 寿
  • Organizer: 第23回日本老年歯科医学会
  • Place of Presentation: 筑波
  • Year and Date: 2012-06-23
• [Presentation] The Effect of Mastication on the Expression of Brain-Derived Neurotrophic Factor in the Rat Brain (2011)
  • Author(s): Watanabe S., Toyoshita Y., Aita H., Koshino H., Hirai, T.
  • Organizer: 14th Biennial Meetingof the International College of Prosthodontists
  • Place of Presentation: Hawaii USA
  • Year and Date: 2011-09-10
• [Presentation] The Effect of Mastication on the Expression of Brain-Derived Neurotrophic Factor in the Rat Brain (2011)
  • Author(s): Watanabe Shinya 、Toyoshita Yoshifumi 、Aita Hideki 、 Koshino Hisashi 、 Hirai, Toshihiro
  • Organizer: 14th Biennial Meetingof the International College of Prosthodontists
  • Place of Presentation: アメリカ合衆国ハワイ
  • Year and Date: 2011-09-09
• [Presentation] 脳梗塞モデルラットにおける神経栄養因子発現への咀嚼の効果 (2011)
  • Author(s): 佐々木みづほ、豊下祥史、渡辺真也、川西克弥、會田英紀、橋川美子、小西洋次 伊東由紀夫、越野 寿、平井敏博
  • Organizer: 社団法人日本補綴歯科学会第120回記念学術大会
  • Place of Presentation: 広島
  • Year and Date: 2011-05-20
• [Presentation] 脳梗塞モデルラットにおける後遺障害の回復に咀嚼が及ぼす影響 (2011)
  • Author(s): 佐々木みづほ、豊下祥史、川西克弥、河野舞、會田英紀、越野 寿
  • Organizer: 口腔先端応用医科学研究会第3回学術会議
  • Place of Presentation: 東京
  • Year and Date: 2011-01-22
• [Presentation] ラットの液体飼料飼育が脳由来神経栄養因子の発現に及ぼす影響 (2010)
  • Author(s): 渡部真也、豊下祥史、會田英紀、越野 寿平井敏博
  • Organizer: 平成 22年度 社団法人日本補綴歯科学会 東北・北海道支部総会ならびに学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2010-10-23
• [Presentation] 脳梗塞モデルラットにおける短期および長期記憶の形成に咀嚼が及ぼす影響 (2010)
  • Author(s): 佐々木みずほ、豊下祥史、川西克弥、越野寿、平井敏博
  • Organizer: 日本咀嚼学会第21回学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-01
• [Presentation] Effect of dental pulp stem cell therapy for cerebral ischemia (2010)
  • Author(s): Toyoshita Yoshifumi 、Koshino Hisashi 、Sasaki Mizuho 、 Kawanishi Katsuya 、Kanazawa Kaoru 、 Aita Hideki 、 Miura Yoshihide 、Hirai Toshihiro
  • Organizer: 88th General Session & Exhibition of the IADR
  • Place of Presentation: スペインバルセロナ
  • Year and Date: 2010-07-15
• [Presentation] Hirai Toshihiro、 Miura Yoshihide、Effects of dental pulp cell transplantation on global ischemia model (2010)
  • Author(s): Kanazawa Kaoru 、Toyoshita Yoshifumi 、Koshino Hisashi
  • Organizer: 88th General Session & Exhibition of the IADR
  • Place of Presentation: スペインバルセロナ
  • Year and Date: 2010-07-15
• [Presentation] Effect of dental pulp stem cell therapy for cerebral ischemia (2010)
  • Author(s): Toyoshita Y, Koshino H, Sasaki M, Kawanishi K, Kanazawa K, Aita H, Miura Y, Hirai T
  • Organizer: 88th General Session & Exhibition of the IADR
  • Place of Presentation: Balcerona Spain
  • Year and Date: 2010-07-15
• [Presentation] Potential for differentiation of dental pulp cells into neuron
  • Author(s): Yoshifumi Toyoshita
  • Organizer: 91th General Session & Exhibition of the IADR
  • Place of Presentation: アメリカ合衆国シアトル
• [Presentation] 脳梗塞モデルラットの脳内における細胞増殖への咀嚼の影響
  • Author(s): 佐々木みづほ
  • Organizer: 日本咀嚼学会第23回総会・学術大会
  • Place of Presentation: 札幌
• [Presentation] 脳梗塞モデルラットにおける海馬歯状回の細胞増殖への咀嚼の影響
  • Author(s): 第23回日本老年歯科医学会
  • Organizer: 第23回日本老年歯科医学会
  • Place of Presentation: 筑波