Study on the function of autophagy and ubiquitin- proteasome systems in the atrophy of tongue and masticatory muscles induced by aging

• Project/Area Number: 22791912
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Prosthetic dentistry
• Research Institution: Tsurumi University
• Principal Investigator: IIDA Ryohei 鶴見大学, 歯学部, 助教 (70339810)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 顎口腔機能学 / 摂食・嚥下機能障害 / 老化 / 口腔周囲筋 / ミオシン重鎖 / 加齢 / Klothoマウス / オートファジー / 咬筋 / 舌筋 / mTOR / 4E-BPI / S6K / オートファジー・リソソーム系 / ユビキチン・プロテアソーム系 / 腓腹筋 / 筋委縮

Research Abstract

In the present study, the mechanism for sarcopenia was explored. The activity of masticatory and tongue muscles such as protein degradation was more active than limb and trunk muscles in aged mice. The influence of aging varied among masticatory and tongue muscles.

Research Products

• [Journal Article] Age-related changes in rat genioglossus, geniohyoid, and masseter muscles (2013)
  • Author(s): KANEKO, S., IIDA, R., SUGA, T., MORITO, M. and YAMANE, A.
  • Journal Title: Gerodontology Volume: 未定 Issue: 1 Pages: 56-62
  • DOI: 10.1111/ger.12004
  • Peer Reviewed
• [Journal Article] IGF and myostatin pathways are respectively induced during the earlier and the later stages of skeletal muscle hypertrophy induced by clenbuterol, abeta2-adrenergic agonist. (2012)
  • Author(s): ABO, T., IIDA, R., KANEKO, S., SUGA, T., YAMADA, H., HAMADA, Y. and YAMANE, A.
  • Journal Title: Cell Biochem. Func. Volume: 30(8) Pages: 671-676
  • Peer Reviewed
• [Journal Article] IGF and myostatin pathways are respectively induced during the earlier and the later stages of skeletal muscle hypertrophy induced by clenbuterol, a b2-adrenergic agonist (2012)
  • Author(s): ABO, T., IIDA, R., KANEKO, S., SUGA, T., YAMADA, H., HAMADA, Y. and YAMANE, A.
  • Journal Title: Cell Biochem. Func. Volume: 30 Issue: 8 Pages: 671-676
  • DOI: 10.1002/cbf.2848
  • Peer Reviewed
• [Journal Article] Changes in triacylglycerol-accumulated fiber type, fiber type composition (2011)
  • Author(s): KANEKO, S., IIDA, R., SUGA, T., FUKUI, T., MORITO, M. and YAMANE, A.
  • Journal Title: biogenesis in the mitochondria of the soleus muscle in obese rats. Anat. Volume: Rec. 294 (11) Pages: 1904-1912
  • Peer Reviewed
• [Journal Article] Autophagic-lysosomal pathway functions in the masseter and tongue muscles in the klotho mouse a mouse model for aging. (2011)
  • Author(s): IIDA, R., KANEKO, S., SUGA, T., MORITO, M. and YAMANE, A.
  • Journal Title: Mol. Cell. Biochem. Volume: 348(1) Pages: 89-98
  • Peer Reviewed
• [Journal Article] Autophagic-lysosomal pathway functions in the masseter and tongue muscles in the klotho mouse, a mouse model for aging (2011)
  • Author(s): IDA, R., KANEKO, S., SUGA, T., MORITO, M., YAMANE, A.
  • Journal Title: Mol.Cell.Biochem. Volume: 348 Issue: 1-2 Pages: 89-98
  • DOI: 10.1007/s11010-010-0642-z
  • Peer Reviewed
• [Journal Article] Changes in triacylglycerol-accumulated fiber type, fiber type composition, biogenesis in the mitochondria of the soleus muscle in obese rats (2011)
  • Author(s): KANEKO, S., IIDA, R., SUGA, T., FUKUI, T., MORITO, M., YAMANE, A.
  • Journal Title: Anat.Rec. Volume: 294 Issue: 11 Pages: 1904-1912
  • DOI: 10.1002/ar.21472
  • Peer Reviewed
• [Journal Article] TGFb3 is expressed in differentiating muscle of the embryonic mouse tongue. (2010)
  • Author(s): YAMANE, A., FUKUI, T., SUGA, T., IIDA, R. and MORITO, M.
  • Journal Title: Int. J. Dev. Volume: Biol.54(1):221-226
  • Peer Reviewed
• [Journal Article] BMP-2 regulates the formation of oral sulcus in mouse tongue by altering the balance between TIMP-1 and MMP-13. (2010)
  • Author(s): FUKUI, T., SUGA, T., IIDA, R., MORITO, M., LUAN, X., DIEKWISCH, T.G.H., NAKAMURA, Y. and YAMANE, A.
  • Journal Title: Anat. Rec Volume: 293(8) Pages: 1408-1415
  • Peer Reviewed
• [Journal Article] Klotho 遺伝子突然変異マウス骨格筋におけるインスリン様増殖因子およびその受容体 mRNA 発現. (2010)
  • Author(s): 飯田良 平 、菅 武雄、山根 明、森戸光彦.
  • Journal Title: 鶴見歯学 Volume: 36(2) Pages: 95-102
  • Peer Reviewed
• [Journal Article] TGFβ3 is expressed in differentiating muscle of the embryonic mouse tongue (2010)
  • Author(s): YAMANE, A., FUKUI, T., SUGA, T., IIDA, R., MORITO, M.
  • Journal Title: Int.J.Dev.Biol. Volume: 54 Pages: 221-226
  • Peer Reviewed
• [Journal Article] BMP-2 regulates the formation of oral sulcus in mouse tongue by altering the balance between TIMP-1 and MMP-13 (2010)
  • Author(s): FUKUI, T., SUGA, T., IIDA, R., MORITO, M., LUAN, X., DIEKWISCH, T.G.H., NAKAMURA, Y., YAMANE, A.
  • Journal Title: Anat.Rec. Volume: 293 Pages: 1408-1415
  • Peer Reviewed
• [Journal Article] Klotho遺伝子突然変異マウス骨格筋におけるインスリン様増殖因子およびその受容体mRNA発現 (2010)
  • Author(s): 飯田良平、菅武雄、山根明、森戸光彦
  • Journal Title: 鶴見歯学雑誌 Volume: 36 Pages: 95-102
  • Peer Reviewed
• [Journal Article] Age-related changes in rat genioglossus, geniohyoid, and masseter muscles.
  • Author(s): KANEKO, S., IIDA, R., SUGA, T., MORITO, M. and YAMANE, A.
  • Journal Title: Gerodontology Volume: (in press)
  • Peer Reviewed
• [Journal Article] IGF and myostatin pathways are respectively induced during the earlier and the later stages of skeletal muscle hypertrophy induced by clenbuterol, a β2-adrenergic agonist
  • Author(s): ABO, T., IIDA, R., KANEKO, S., SUGA, T., YAMADA, H., HAMADA, Y., YAMANE, A.
  • Journal Title: Cell Biochem.Func.In press
  • Peer Reviewed
• [Presentation] Klothoマウスの舌、咬筋のサルコペニア発症にオートファジー蛋白質分解系が機能している (2012)
  • Author(s): 山根明、飯田良平、金子周平、菅武雄、森戸光彦
  • Organizer: 第85回日本薬理学会年会
  • Place of Presentation: 国立京都国際会館、京都
  • Year and Date: 2012-03-16
• [Presentation] Changes in the property of rat genioglossus, geniohyoid and masseter muscles in assoication with aging (2011)
  • Author(s): YAMANE, A., KANEKO, S., IIDA, R., SUGA, T., MORITO, M.
  • Organizer: 第43回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜、神奈川
  • Year and Date: 2011-12-16
• [Presentation] ラット咬筋、オトガイ舌筋、オトガイ舌骨筋の老化過程におけるミオシン重鎖の発現変化 (2011)
  • Author(s): 金子周平、飯田良平、菅武雄、山根明、森戸光彦
  • Organizer: 日本老年歯科医学会第22回学術大会
  • Place of Presentation: 京王プラザホテル、東京
  • Year and Date: 2011-06-16
• [Presentation] Cooperative functions of myostatin and IGF in the regulatory mechanism for the hypertrophy of rat masseter muscle induced with clenbuterol, a β2-adrenergic agonist (2011)
  • Author(s): YAMANE, A., ABO, T., IIDA, R., SUGA, T., KANEKO, S., FUKUI, T.
  • Organizer: International Conference on Muscle Wasting 2001
  • Place of Presentation: Centro Stefano Franscini, Ascona, Switzerland
• [Presentation] ラット骨格筋において高脂肪食摂取によりトリアシルグルセロールの蓄積される筋線維タイプについて (2010)
  • Author(s): 金子周平、飯田良平、菅武雄、山根明、森戸光彦
  • Organizer: 第21回日本老年歯科医学会総会・学術大会
  • Place of Presentation: 朱鷺メッセ、新潟コンベンションセンター