Influence of trkB gene polymorphism on BDNF-induced periodontal tissue regeneration
| Project/Area Number |
22791929
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 再生歯学 / BDNF / 歯周組織再生 / 個体の感受性 |
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| Research Abstract |
We planned to clarify the characteristics of BDNF-induced periodontal tissue regeneration, and to investigate the genetic association of trkB with periodontal tissue regeneration by BDNF. In vitro study, two weeks after the BDNF application, periodontal tissue regeneration was insufficient, but invasion of epithelial cells to defects was not observed. TrkB, PCNA and OPN-positive cells were detected on the denuded root surface, around the regenerating alveolar bone and in the soft connective tissue of regenerating periodontal tissues. TrkB positive cells may quickly responded to applied BDNF and started to proliferate and differentiate for the periodontal tissue regeneration within 2 weeks. Furthermore, we investigated the trkB single nucleotide polymorphisms(SNPs) which are reported to have some relationships with Alzheimer' s disease.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Characteristics of High-Molecular-Weight Hyaluronic Acidas a Brain-Derived Neurotrophic Factor Scaffold in Periodontal Tissue Regeneration2011
Author(s)
Takeda K, Sakai N, ShibaH, Nagahara T, Fujita T, Kajiya M, Iwata T, Matsuda S, Kawahara K, Kawaguchi H, Kurihara H
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Journal Title
Tissue EngPart A
Volume: 17(7-8)
Pages: 955-67
Related Report
Peer Reviewed
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