A development of the comprehensive tooth regenerative therapy by the bioengineered tooth unit transplantation.
| Project/Area Number |
22791941
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 再生 / 歯 / 器官形成 / 器官発生 / 幹細胞 |
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| Research Abstract |
In current research on whole-tooth regenerative therapy, a basic strategy is being pursued in which a bioengineered tooth germ is induced to develop into a fully functional tooth. We demonstrate the successful transplantation of a bioengineered tooth unit, which is a model for a mature bioengineered organ, into a missing tooth region in vivo and the subsequent restoration of tooth function by this graft. We also show that this transplantation can restore the bone volume in both the vertical and horizontal dimensions in a missing tooth mouse model with a serious extensive bone defect. These findings indicate that whole tooth regenerative therapy is feasible through the transplantation of a bioengineered mature tooth unit. This study also provides the first reported evidence of entire organ regeneration through the transplantation of a bioengineered mature organ.
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Report
(3 results)
Research Products
(66 results)
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[Journal Article] Functional tooth regeneration using a bioengineered tooth unit as a mature organ replacement regenerative therapy2011
Author(s)
Masamitsu Oshima, Mitsumasa Mizuno, Aya Imamura, Miho Ogawa, Masato Yasukawa, Hiromichi Yamazaki, Ritsuko Morita, Etsuko Ikeda, Kazuhisa Nakao, Teruko Takano-Yamamoto, Shohei Kasugai, Masahiro Saito and Takashi Tsuji
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Journal Title
Related Report
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[Journal Article] ADAMTSL6β rescues fibrillin-1 microfibril disorder in Marfan syndrome mouse model through the promotion of fibrillin-1 assembly2011
Author(s)
Masahiro Saito, Misaki Kurokawa, Masahito Oda, Masamitsu Oshima, Ko Tsutsui, Kazutaka Kosaka, Kazuhisa Nakao, Miho Ogawa, Ri-ichiroh Manabe, Naoto Suda, Ganburged Ganjargal, Yasunobu Hada, Toshihide Noguchi, Toshio Teranaka, Kiyotoshi Sekiguchi, Toshiyuki Yoneda and Takashi Tsuji.
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Journal Title
Journal of Biological Chemistry
Volume: 286(44)
Pages: 38602-38613
Related Report
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