Establishment of a safe gene therapy for pain management

• Project/Area Number: 22791951
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Tohoku University
• Principal Investigator: ATSUKO Matoba 東北大学, 大学院・歯学研究科, 助教 (70547257)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ナノバブル / 分子導入 / 術後疼痛制御

Research Abstract

Intrathecal administration of pain-related drugs and nanobubbles extended duration of antinociceptive action in a postoperative pain rat model. Pain-related gene transfer into surgical site with nanobubbles also produced antinociceptive effectson heat and mechanical stimuli.
These results suggest that introducing pain-related molecules into surgical site or spinal cord using nanobubbles extends the duration of action and produces antinociceptive effect safely.

Research Products

• [Journal Article] Efficacy of intrathecal esmolol on heat evoked responses in a postoperative pain model (2013)
  • Author(s): Ono H, Ohtani N, Matoba A, Kido K, YasuiY, Masaki E.
  • Journal Title: American Journal of Therapeutics Volume: (in press)
  • Peer Reviewed
• [Journal Article] 全身麻酔下歯科治療後に代理ミュンヒハウゼン症候群を強く疑うにいたった一例 (2012)
  • Author(s): 渡辺泰輔、水田健太郎、猪狩敏郎、門馬祐子、的場あつ子、正木英二
  • Journal Title: 日本歯科麻酔学会雑誌 Volume: 40(2) Pages: 227-228
  • Peer Reviewed
• [Journal Article] Evaluation of transfection efficiency in skeletal muscle using nano/microbubbles and ultrasound (2010)
  • Author(s): Kodama T, Aoi A, Watanabe Y, Horie S, Kodama M, Li L, Chen R, Teramoto N, Morikawa H, Mori S, Fukumoto M.
  • Journal Title: Ultrasound Med Biol Volume: 36(7) Issue: 7 Pages: 1196-205
  • DOI: 10.1016/j.ultrasmedbio.2010.04.016
  • Peer Reviewed
• [Presentation] Efficacy of intrathecal minocycline on heat and mechanical stimuli evoked response in a postoperative pain model American Society of Anesthesiologists (2012)
  • Author(s): Ono H, Matoba A, Kido K, Wayanabe D, Ohtani N,Masaki E.
  • Organizer: 2012 Annual meeting
  • Place of Presentation: USAワシントン
  • Year and Date: 2012-10-14
• [Presentation] ミノサイクリン脊髄腔内投与の術後痛モデルラットにおける抗侵害作用 (2012)
  • Author(s): 小野瞳、的場あつ子、佐藤港、堀之内節、正木英二
  • Organizer: 第59回日本麻酔科学会学術集会
  • Place of Presentation: 神戸市
  • Year and Date: 2012-06-08
• [Presentation] Perioperative Infusion of Dexmedetomidine Decreases Analgesic consumption:A Meta-Analysis (2011)
  • Author(s): 小野瞳、 的場あつ子 、渡辺泰輔、正木英二
  • Organizer: 第3回 Evidence-based Anesthesia研究会
  • Place of Presentation: 那覇市
  • Year and Date: 2011-11-05
• [Presentation] Perioperative infusion of dexmedetomidine decreses analgesic consumption : A meta-analysis (2011)
  • Author(s): 的場(青井)あつ子
  • Organizer: 第3回Evidence-based Anesthesia研究会
  • Place of Presentation: 沖縄
  • Year and Date: 2011-11-05
• [Presentation] ナノバブルとエスモロール脊髄腔内投与の術後疼痛モデルラットにおける抗侵害作用 (2011)
  • Author(s): 小野瞳、的場あつ子、正木英二
  • Organizer: 第39回日本歯科麻酔学会学術集会
  • Place of Presentation: 神戸市
  • Year and Date: 2011-10-08
• [Presentation] Assessment of blood loss in bone surgery under hypotensive anesthesia (2010)
  • Author(s): 的場あつ子、小野瞳、正木英二
  • Organizer: 第2回Evidence-based Anesthesia研究会
  • Place of Presentation: 徳島市
  • Year and Date: 2010-11-06
• [Presentation] Assessment of blood loss in bone surgery under hypotensive anesthesia (2010)
  • Author(s): 的場あつ子
  • Organizer: Evidence-based Anesthesia研究会
  • Place of Presentation: 徳島
  • Year and Date: 2010-11-06
• [Presentation] Efficacy of intrathecal esmolol of heat evoked responses in a postoperative pain model (2010)
  • Author(s): Ohtani N, Tachibana Y, Aoi A, Yasui Y, Masaki E.
  • Organizer: American Society of Anesthesiologists 2010 Annual meeting
  • Place of Presentation: USAサンディエゴ
  • Year and Date: 2010-10-18
• [Presentation] 多剤に対するアナフィラキシーを頻回に起こした1症例 (2010)
  • Author(s): 青井あつ子、水田健太郎、正木英二
  • Organizer: 第38回日本歯科麻酔学会学術集会
  • Place of Presentation: 横須賀市
  • Year and Date: 2010-10-08
• [Presentation] 多剤アレルギーの既往を有する患者の全身麻酔下歯科治療経験 (2010)
  • Author(s): 青井あつ子、渡辺泰輔、水田健太郎、正木英二
  • Organizer: 第25回歯科麻酔学会東北地方会
  • Place of Presentation: 秋田市
  • Year and Date: 2010-08-01
• [Presentation] ナノバブルと超音波を用いたGDNF遺伝子導入が術後疼痛に及ぼす影響
  • Author(s): 的場あつ子
  • Organizer: 日本麻酔科学会 第60回学術集会
  • Place of Presentation: 札幌