| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
(2010)(1) B16 melanoma were purchased from RIKEN, incubated for proliferation. (2) Anticancer drug, 5-FU were administered to WT mice(C57BL/6), and myelosuppression was observed, so called nadir, at 7days Flowcytometry and HE staining. (3) An adjuvant CpG were administered, the production of inflammatory cytokine were observed by ELISA. (2011) (1) B16 melanoma were inoculated s.c., as a result, confirmed engrafted model. Myeloid derived suplessive cells(MDSC) resident in peripheral blood at 8%, but 7days after 5-FU injection, MDSC were decreased at 4%. On the other, 5-FU and CpG combined injected, MDSC were increased at 20%.
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