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Functional analysis of the bone differentiation from isolated mesenchymal stem cell from the apical pulp of human teeth

Research Project

Project/Area Number 22791954
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionUniversity of Tsukuba

Principal Investigator

YAMAGATA Kenji  筑波大学, 医学医療系, 講師 (00420084)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords骨分化能 / 間葉系幹細胞(MSCs) / 骨折モデルマウス / 智歯歯髄 / CD349 / 歯由来間葉系細胞 / 根尖部歯髄組織 / Aldehyde dehydrogenase活性 / 智歯
Research Abstract

The purpose of this study was to analyze the function of the bone differentiation for isolated mesenchymal stem cells (MSCs) from the apical pulp of human teeth. Function of bone differentiation was higher in the stage of completed root formation than other stages in vitro. The CD349 (+) MSCs which were isolated from CD349 marker expressing the function of bone formation were excellent for bone differentiation in vivo.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (4 results)

All 2011

All Presentation (4 results)

  • [Presentation] ヒト智歯歯髄由来間葉系幹細胞の骨分化能に対する機能解析2011

    • Author(s)
      山縣憲司, 長野真澄, 木村健一, 菊地豪, 佐々木裕芳, 瀬戸佳穂里, 内田文彦,柳川徹, 鬼澤浩司郎, 武川寛樹, 大根田修
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト智歯歯髄由来間葉系幹細胞の骨分化能に対する機能解析2011

    • Author(s)
      山縣憲司, 他
    • Organizer
      日本口腔外科学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 発生段階に応じたヒト歯髄由来間葉系幹細胞の機能解析2011

    • Author(s)
      山崎加奈子、木村健一、山縣憲司、長野真澄、大根田修
    • Organizer
      日本再生医療学会
    • Place of Presentation
      東京、京王プラザ
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 発生段階に応じたヒト歯髄由来間葉系幹細胞の機能解析2011

    • Author(s)
      山崎加奈子, 木村健一, 山縣憲司, 長野真澄, 大根田修
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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