Functional analysis of the bone differentiation from isolated mesenchymal stem cell from the apical pulp of human teeth

Research Project

Project/Area Number	22791954
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	University of Tsukuba
Principal Investigator	YAMAGATA Kenji 筑波大学, 医学医療系, 講師 (00420084)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	骨分化能 / 間葉系幹細胞(MSCs) / 骨折モデルマウス / 智歯歯髄 / CD349 / 歯由来間葉系細胞 / 根尖部歯髄組織 / Aldehyde dehydrogenase活性 / 智歯
Research Abstract	The purpose of this study was to analyze the function of the bone differentiation for isolated mesenchymal stem cells (MSCs) from the apical pulp of human teeth. Function of bone differentiation was higher in the stage of completed root formation than other stages in vitro. The CD349 (+) MSCs which were isolated from CD349 marker expressing the function of bone formation were excellent for bone differentiation in vivo.

Report

(3 results)