Elucidation of epigenetic abnormalities which lead oral malignancy from oral premalignant lesion

• Project/Area Number: 22791955
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: The University of Tokyo
• Principal Investigator: ABE Masanobu 東京大学, 医学部附属病院, 助教 (10392333)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 臨床腫瘍学 / エピジェネティクス / 口腔癌 / 口腔前癌病変

Research Abstract

324 of highly methylated genes at promoter region were identified by MeDIP-CGI microarray assay in oral squamous cell carcinoma cell lines(Ca9-22, HSC-2). Furthermore, the global expression levels between before and after 5-aza-dC treatment in oral squamous cell carcinoma cell lines(Ca9-22, HSC-2) were analyzed and 351 of highly up-regulated genes by the treatment were identified. Finally, 125 of silencing genes by promoter methylation were identified in oral squamous cell carcinoma cell lines.

Research Products

• [Presentation] 口腔前癌病変悪性化におけるエピジェネティクスを指標としたリスクマーカーのゲノム網羅的探索 (2011)
  • Author(s): 阿部雅修
  • Organizer: 第29回日本口腔腫瘍学会総会
  • Place of Presentation: 崇城大学市民ホール(熊本)
  • Year and Date: 2011-01-27
• [Presentation] 口腔前癌病変悪性化におけるエピジェネティクスを指標としたリスクマーカーのゲノム網羅的探索 (2011)
  • Author(s): 阿部雅修、森良之、西條英人、安部貴大、杉山円、古賀陽子、高戸毅
  • Organizer: 第35回日本頭頚部癌学会
  • Place of Presentation: 愛知
• [Presentation] DNAメチル化異常を指標とした口腔前癌病変悪性化のリスクマーカーの探索 (2011)
  • Author(s): 阿部雅修、森良之、西條英人、杉山円、高戸毅
  • Organizer: 第29回日本口腔腫瘍学会総会・学術大会
  • Place of Presentation: 熊本