| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
An important tool of cancer therapy in 21th century is a molecular targeting therapy. However there are a little studies to focused on distant metastasis and lymph node metastasis which occur frequently on oral squamous cell carcinoma. Combinations of safingol, which induced apoptosis caspase independent manner and GGTI-298, new molecular target drug, exhibited synergistic effect. GGTI-298 and safingol inhibited cell growth synergistically and increased the number of apoptotic cells. Combination of safingol and GGTI-298 may be a candidate for the treatment of oral SCC targeting for anticancer drug resistance and suppression of metastasis because safingol have antitumor effect and GGTI-298 suppress metastasis.
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