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The sensibility of chemoradiotherapy in oral squamous cell carcinoma cells transfected with HPV-E6/ E7 gene

Research Project

Project/Area Number 22791974
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionOsaka University

Principal Investigator

ISHIBASHI Miki  大阪大学, 大学院・歯学研究科, 招聘教員 (40412051)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords口腔癌 / HPV / 治療感受性 / 分子生物学 / 口腔扁平上皮癌 / 放射線化学療法 / 口腔多発癌
Research Abstract

The aim of this study was to clarify the sensibility of chemoradiotherapy in HPV-positive oral squamous cell carcinomas. Briefly, we evaluated the frequency of HPV infection in oral lesions, and p16^<INK4a>、p53、CD4、CD8、CD68、CD1a Ctr1 were immunohistochemically examined in order to evaluate its correlation with HPV infection. In oral lesions, the total HPV-positive rate was 22. 4%. We did not find significant correlation immunohistochemically with HPV infection. The sensibility of chemoradiotherapy in HPV-positive cases depend on, suggesting the involvement of other factors.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2012 2011 2010

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (10 results)

  • [Journal Article] The prevalence of human papillomavirus in oral premalignant lesions and squamous cell carcinoma in comparison to cervical lesions used as a positive control2011

    • Author(s)
      Ishibashi M, Kishino M, Morii E, Ogawa Y, Aozasa K, Kogo M, Toyosawa S.
    • Journal Title

      Int J Clin Oncol

      Volume: 16(6) Pages: 646-53

    • NAID

      10030247285

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 下顎骨に発生したエナメル上皮線維肉腫の1例2011

    • Author(s)
      美馬孝至, 鏡内肇, 横田祐介, 石橋美樹, 石井庄一郎, 岸野万伸
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 57巻2号 Pages: 78-82

    • NAID

      10030271559

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The prevalence of human papillomavirus in oral premalignant lesions and squamous cell carcinoma in comparison to cervical lesions used as a positive control2011

    • Author(s)
      Miki Ishibashi
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 16 Issue: 6 Pages: 646-653

    • DOI

      10.1007/s10147-011-0341-0

    • NAID

      10030247285

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central odontogenic fibroma of the maxilla : a case report with immunohistochemical study2010

    • Author(s)
      Kishino Mitsunobu, Ishibashi Miki, Koizumi Hidehiko, Sato Sunao, Murakami Shumei, Ogawa Yuzo, Kogo Mikihiko, Toyosawa Satoru
    • Journal Title

      Oral Medicine & Pathology

      Volume: 14巻1 Pages: 29-32

    • NAID

      130004850532

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 口唇裂・口蓋裂に伴う上顎骨裂成長に対する上顎骨前方部骨延長術(MASDO)についての臨床的検討2012

    • Author(s)
      牛村彩子、原田丈司、相川友直、石濱孝二、樋口将隆、永谷俊介、奥野恵実、山本奈緒、木田久美子、田中輝、程壮樹、田中晋、石橋美樹、飯田征二、古郷幹彦
    • Organizer
      第42回日本口腔外科学会近畿地方会
    • Place of Presentation
      大阪
    • Year and Date
      2012-06-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 口腔多発癌と膀胱癌の同時性重複癌の1例2012

    • Author(s)
      石橋美樹
    • Organizer
      日本口腔腫瘍学会総会
    • Place of Presentation
      大宮ソニックシティー(埼玉県)
    • Year and Date
      2012-01-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 口腔多発癌と膀胱癌の同時性重複癌の1例2012

    • Author(s)
      石橋美樹、住岡聡、石本俊介、石井庄一郎、美馬孝至
    • Organizer
      第30回日本口腔腫瘍学会総会・学術大会
    • Place of Presentation
      埼玉
    • Related Report
      2011 Final Research Report
  • [Presentation] 上顎歯肉に再発した悪性リンパ腫の1例2011

    • Author(s)
      石橋美樹, 住岡聡, 横田祐介, 美馬孝至
    • Organizer
      第56回日本口腔外科学会総会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] NTT西日本大阪病院歯科口腔外科における外科矯正手術症例の臨床統計的観察2011

    • Author(s)
      住岡聡, 石橋美樹, 横田祐介, 増田智丈, 美馬孝至
    • Organizer
      第56回日本口腔外科学会総会
    • Place of Presentation
      大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] 口唇裂・口蓋裂に伴う上顎骨劣成長に対する上顎骨前方部骨延長術(MASDO)の検討2011

    • Author(s)
      原田丈司, 相川友直, 石濱孝二, 樋口将隆, 牛村彩子, 田中晋, 石橋美樹, 永谷俊介, 奥野恵実, 山本奈穂, 木田久美子, 田中輝, 程壮樹, 飯田征二, 古郷幹彦
    • Organizer
      第21回日本顎変形症学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 含歯性嚢胞から発生したと考えられる顎骨中心性扁平上皮癌の1例2010

    • Author(s)
      岸野万伸、相川友直、石橋美樹、村上秀明、福田康夫、豊澤悟
    • Organizer
      第49回日本病理学会近畿支部学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-05-15
    • Related Report
      2011 Final Research Report
  • [Presentation] 口腔扁平上皮癌における詳細な頸部リンパ節転移部位の検討2010

    • Author(s)
      住岡聡, 大倉正也, 相川友直, 田中徳昭, 沢井奈津子, 徳宮元富, 石橋美樹, 古郷幹彦
    • Organizer
      第56回日本口腔外科学会総会
    • Place of Presentation
      千葉
    • Related Report
      2011 Final Research Report
  • [Presentation] オトガイ下引き抜き法による挿管を行い顎矯正手術を行った外鼻欠損の1例2010

    • Author(s)
      石橋美樹, 相川友直, 田中晋, 磯村恵美子, 古郷幹彦, 飯田征二
    • Organizer
      第20回日本顎変形症学会総会
    • Place of Presentation
      札幌
    • Related Report
      2011 Final Research Report
  • [Presentation] Hybrid型延長装置を用いて側方回転を伴う上顎骨前方部の骨延長術を行った唇顎口蓋裂症例2010

    • Author(s)
      田中晋, 飯田征二, 相川友直, 石橋美樹, 阿部早苗, 古郷幹彦
    • Organizer
      第34回日本口蓋裂学会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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