The exhaustive analysis of proteins related with STAT signaling and the possibilities for new treatments of oral cancer patients
Project/Area Number |
22791987
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Surgical dentistry
|
Research Institution | Ehime University |
Principal Investigator |
ISHIKAWA Akiko 愛媛大学, 大学院・医学系研究科, 講師 (90444760)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 口腔癌 / STAT / 細胞間接着 / E-カドヘリン |
Research Abstract |
STAT signaling is activated by E-cadherin binding following cell-cell adhesions, which lead the avoidance of cancer cells death. This study showed that both Rac1 and Cdc42 were phosphorylated after cell-cell adhesions. As the result of STAT3 inhibition by using siRNA, STAT3 activation promotes cancer cell activity by avoiding cells death, but little affects cell growth, migration and invasion.
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Report
(3 results)
Research Products
(5 results)