| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
STAT signaling is activated by E-cadherin binding following cell-cell adhesions, which lead the avoidance of cancer cells death. This study showed that both Rac1 and Cdc42 were phosphorylated after cell-cell adhesions. As the result of STAT3 inhibition by using siRNA, STAT3 activation promotes cancer cell activity by avoiding cells death, but little affects cell growth, migration and invasion.
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