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Molecular biological study on the pathogenesis of a novel clinical entity, Mikulicz's disease/ IgG4-related diseas

Research Project

Project/Area Number 22791990
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionKyushu University

Principal Investigator

MORIYAMA Masafumi  九州大学, 大学病院, 医員 (20452774)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsIgG4関連疾患 / ミクリッツ病 / Thサブセット / サイトカイン / シェーグレン症候群 / 自己免疫疾患 / ケモカイン
Research Abstract

Mikulicz’s disease (MD) shows a high-frequency GCs formation in the salivary glands. Recent studies reported that IL-21 mainly produced by T follicular (Tfh) cells is provided help to germinal centers (GCs) formation and involved in a class switching of IgG4. In this study, we thus examined the expression of IL-21 in MD and Sjogren’s syndrome (SS) patients. As the results, IL-21 and CXCR5 were detected in/around GCs from both SS and MD patients. Interestingly, IL-21 was also detected in infiltrating lymphocytes outside GCs from only MD patients. The expression of Th2-related molecules was similar to that of IL-21, while IL-17 was rarely seen in MD. Furthermore, the expression of IL-21 in the LSGs was correlated with the IgG4/IgG ratio in MD. These results suggest that overexpression of IL-21 by Th2 cells might play a key role in GCs formation and IgG4 production in MD

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (36 results)

All 2013 2012 2011 2010 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (14 results) (of which Invited: 2 results) Book (6 results)

  • [Journal Article] Validation of different sets of criteria for the diagnosis of Sjögren's syndrome in Japanese patients.2013

    • Author(s)
      Tsuboi H
    • Journal Title

      Mod Rheumatol.

      Volume: 23 Issue: 2 Pages: 219-225

    • DOI

      10.1007/s10165-012-0812-9

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-21 contributes to germinal centre formation and immunoglobulin G4 production in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease.2012

    • Author(s)
      Maehara T, Moriyama M (Corresponding author), et al
    • Journal Title

      Ann Rheum Dis

      Volume: 71 Pages: 2011-2020

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Th2 and regulatory immune reactions contribute to IgG4 production and the initiation of Mikulicz disease2012

    • Author(s)
      Tanaka A, Moriyama M, et al
    • Journal Title

      Arthritis Rheum

      Volume: 64(1) Pages: 254-63

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytokine/chemokine profiles contribute to understanding the pathogenesis and diagnosis of primary Sjogren's syndrome2012

    • Author(s)
      Moriyama M, Hayashida JN, et al
    • Journal Title

      Clin Exp Immunol

      Volume: 169(1) Pages: 17-26

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective localization of T helper subsets in labial salivary glands from primary Sjogren's syndrome patients.2012

    • Author(s)
      Maehara T, Moriyama M, et al.
    • Journal Title

      Clin Exp Immunol

      Volume: 169(2) Pages: 89-99

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics of Mikulicz's disease as an IgG4-related disease.2012

    • Author(s)
      Moriyama M, Tanaka A, et al
    • Journal Title

      Clin Oral Invest

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of IgG4 class switch-related molecules in IgG4-related disease2012

    • Author(s)
      Tsuboi H, Matsuo N, Iizuka M, Tsuzuki S, Kondo Y, Tanaka A, Moriyama M, et al
    • Journal Title

      Arthritis Res Ther

      Volume: 14(4)

    • NAID

      120007137060

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Validation of different sets of criteria for the diagnosis of Sjogren's syndrome in Japanese patients2012

    • Author(s)
      Tsuboi H, Hagiwara S, Asashima H, Umehara H, Kawakami A, Nakamura H, Sano H, Tsubota K, Ogawa Y, Takamura E, Saito I, Inoue H, Nakamura S, Moriyama M, et al
    • Journal Title

      Mod Rheumatol

      Volume: (in press)

    • NAID

      10031167692

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-21 contributes to germinal centre formation and immunoglobulin G4 production in IgG4-related dacryoadenitis and sialoadenitis, so-called Mikulicz's disease.2012

    • Author(s)
      Maehara T
    • Journal Title

      Ann Rheum Dis.

      Volume: 71 Issue: 12 Pages: 2011-2020

    • DOI

      10.1136/annrheumdis-2012-201477

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Th2 and regulatory immune reactions contributes to IgG4 production and the initiation of Mikulicz's disease2012

    • Author(s)
      A Tanaka, M Moriyama, et al
    • Journal Title

      Arthritis & Rheumatism

      Volume: 64 Issue: 1 Pages: 254-263

    • DOI

      10.1002/art.33320

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics of Mikulicz’s disease as an IgG4-related disease.2012

    • Author(s)
      Moriyama M
    • Journal Title

      Clin Oral Invest

      Volume: [Epub ahead of print]

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective localization of T helper subsets in labial salivary glands from primary Sjögren's syndrome patients.2012

    • Author(s)
      Maehara T
    • Journal Title

      Clin Exp Immunol.

      Volume: 69 Issue: 2 Pages: 89-99

    • DOI

      10.1111/j.1365-2249.2012.04606.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytokine/chemokine profiles contribute to understanding the pathogenesis and diagnosis of primary Sjögren’s syndrome.2012

    • Author(s)
      Moriyama M
    • Journal Title

      Clin Exp Immunol.

      Volume: 169 Issue: 1 Pages: 17-26

    • DOI

      10.1111/j.1365-2249.2012.04587.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of IgG4 class switch-related molecules in IgG4-related disease.2012

    • Author(s)
      Tsuboi H
    • Journal Title

      Arthritis Res Ther

      Volume: 14(4) Pages: 171-171

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An amplification of IL-10 and TGF-beta in patients with IgG4-related tubulointerstitial nephritis.2010

    • Author(s)
      Nakashima H, Miyake K, Moriyama M, et al
    • Journal Title

      Clin Nephrol.

      Volume: 73(5) Pages: 385-91

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] An amplification of IL-10 and TGF-beta in patients with IgG4-related tubulointerstitial nephritis.2010

    • Author(s)
      H Nakashima, K Miyake, M Moriyama, et al.
    • Journal Title

      Clinical Nephrology

      Volume: 73 Pages: 385-391

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] IgG4関連涙腺・唾液腺炎(IgG4-DS)の病態形成における IL-33 の関与2013

    • Author(s)
      古川 祥子
    • Organizer
      第7回 IgG4研究会
    • Place of Presentation
      岡山
    • Related Report
      2012 Annual Research Report
  • [Presentation] ドライマウスならびに関連疾患の診断基準の up to date2012

    • Author(s)
      森山 雅文
    • Organizer
      第11回 九州シェーグレン症候群研究会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] シェーグレン症候群の病態形成におけるThサブセットの関与2012

    • Author(s)
      森山 雅文
    • Organizer
      第21回 日本シェーグレン症候群学会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Clinical characteristics of one of IgG4-related diseases, Mikulicz's disease2011

    • Author(s)
      M Moriyama, et al
    • Organizer
      第61回ドイツ口腔外科学会
    • Place of Presentation
      バンベルグ、ドイツ
    • Year and Date
      2011-06-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] ミクリッツ病/IgG4関連疾患の病態形成におけるサイトカイン・ケモカイン・ケモカインレセプターの関与2011

    • Author(s)
      森山雅文
    • Organizer
      第5回福岡膠原病研究会
    • Place of Presentation
      ホテル日航福岡
    • Year and Date
      2011-02-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] IgG4と免疫疾患 IgG4関連疾患におけるIgG4クラススイッチ関連分子の解析

    • Author(s)
      坪井洋人, 松尾直美, 飯塚麻菜, 中村友美, 田中昭彦, 森山雅文, 他
    • Organizer
      第55回日本リウマチ学会総会・学術集 会
    • Related Report
      2012 Final Research Report
  • [Presentation] ドライマウスにおけるシェーグレン症候群の鑑別診断

    • Author(s)
      田中昭彦、森山雅文、他
    • Organizer
      第56回 日本口腔外科学会総会・学術大会
    • Related Report
      2012 Final Research Report
  • [Presentation] シェーグレン症候群の病変局所におけるTh サブセットの局在に関する検討

    • Author(s)
      前原隆、森山雅文、他
    • Organizer
      第56回 日本口腔外科学会総会・学術大会
    • Related Report
      2012 Final Research Report
  • [Presentation] Involvement of cytokines in the pathogenesis of Mikulicz's disease

    • Author(s)
      Tanaka A, Moriyama M, et al
    • Organizer
      11th International Symposium on Sjogren's Syndrome
    • Related Report
      2012 Final Research Report
  • [Presentation] Localization of Th subsets in salivary glands of Sjogren's syndrome

    • Author(s)
      Maehara T, Moriyama M, et al
    • Organizer
      11th International Symposium on Sjogren's Syndrome
    • Related Report
      2012 Final Research Report
  • [Presentation] ミクリッツ病 / IgG4関連疾患の病態形成におけるサイトカインの関連についての検討

    • Author(s)
      田中昭彦、森山雅文、他
    • Organizer
      第65回 日本口腔科学会学術集会
    • Related Report
      2012 Final Research Report
  • [Presentation] Localization of Th subsets in salivary glands of Sjogren's syndrome.

    • Author(s)
      Maehara T, Moriyama M, et al
    • Organizer
      The 59th Annual Meeting of Japanese Association for Dental Research
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of IgG4 class switch related molecules in IgG4-related diseas

    • Author(s)
      坪井洋人, 松尾直美, 飯塚麻菜, 中村友美, 田中昭彦, 森山雅文, 他
    • Organizer
      第40回日本免疫学会学術集会
    • Related Report
      2012 Final Research Report
  • [Presentation] IgG4関連疾患におけるIgG4クラススイッチ関連分子の解析

    • Author(s)
      坪井洋人、松尾直美、飯塚麻菜、田中昭彦、森山雅文、他
    • Organizer
      第20回に本シェーグレン症候群学会
    • Related Report
      2012 Final Research Report
  • [Book] 「IgG4関連疾患アトラス」、川 茂幸、川野充弘 編:ミクリッツ病における唾液腺病変2012

    • Author(s)
      森山雅文、中村誠司
    • Publisher
      前田書店
    • Related Report
      2012 Final Research Report
  • [Book] 「特集 IgG4関連疾患 ~21世紀に生まれた新たな疾患概念~」、ミクリッツ病/IgG4関連疾患の病態形成におけるサイトカインの関与2012

    • Author(s)
      森山雅文、中村誠司
    • Publisher
      最新医学社
    • Related Report
      2012 Final Research Report
  • [Book] IgG4関連疾患アトラス2012

    • Author(s)
      森山 雅文
    • Total Pages
      199
    • Publisher
      前田書店
    • Related Report
      2012 Annual Research Report
  • [Book] 最新医学 4月号 20122012

    • Author(s)
      森山 雅文
    • Total Pages
      145
    • Publisher
      最新医学社
    • Related Report
      2012 Annual Research Report
  • [Book] ミクリッツ病における唾液腺病変2012

    • Author(s)
      森山雅文、中村誠司
    • Total Pages
      7
    • Publisher
      前野書店
    • Related Report
      2011 Annual Research Report
  • [Book] IgG4関連疾患への誘い」、川 茂幸、川野充弘 編:ミクリッツ病/IgG4関連疾患とシェーグレン症候群の唾液腺病変における相違点2010

    • Author(s)
      森山雅文、大山順子、他
    • Publisher
      前田書店
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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