Evaluation of the taste disorder generation mechanism and development of the cure with fluoropyrimidine anticancer drugs.
| Project/Area Number |
22792001
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Nara Medical University |
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Principal Investigator |
AOKI Kumiko 奈良県立医科大学, 医学科口腔外科学, 助教 (40448767)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 味覚障害 / 抗がん剤 |
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| Research Abstract |
Although taste disorders are frequently observed in cancer patients undergoing chemotherapy, generation mechanism is unknown. The aim of the study was to reveal generation mechanism of taste disorders. In S-1 administered rats, no morphologic changes in mucosal epithelia basal cells and taste buds were observed. Immunohistochemical staining for a neuronal marker, PGP 9.5, detected nerve fibers in the epithelium and subepithelium of the taste bud. And degeneration of taste cells in the ganglia was significantly increased. The taste disorders by the anticancer drug administration do not generate from the impairment of mucosal epithelia and taste bud, but possibility from neuropathy of the gustatory nerve.
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Report
(3 results)
Research Products
(6 results)
