Elucidation of the nerve - immune system mechanism of facial cancer-induced pain in nucleus of spinal tract of trigeminal nerve.
| Project/Area Number |
22792003
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIIBA Shunji 九州歯科大学, 歯科侵襲制御学分野, 准教授 (20285472)
ONO Kentaro 九州歯科大学, 生理学講座, 准教授 (40316154)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 癌性疼痛 / 神経因性疼痛 / 三叉神経脊髄路核 / 機械刺激疼痛閾値 / 熱刺激逃避 / グルーミング時間 |
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| Research Abstract |
Many advanced and terminal cancer patients must cope with chronic pain. In orofacial cancer patients, pain can readily lead more severe symptoms than found in cancers of other regions. Because cancer pain is sometimes intractable, there is an urgent need to improve the quality of life of patients with incurable cancer and seek means to prevent the development of cancer pain. Therefore, to study effect of cancer on the trigeminal nerve, we have developed a rat facial cancer model and have revealed some characteristics in the mechanisms of facial cancer-induced pain.
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] Distinct time courses of microglial and astrocytic hyperactivation and the glial contribution to pain hypersensitivity in a facial cancer model2012
Author(s)
Sago Teppei, Ono Kentaro, Harano Nozomu, Furuta-Hidaka Kazumi, Hitomi Suzuro, Nunomaki Masahito, Yoshida Mistuhiro, Shiiba Shunji, Nakanishi Osamu, Matsuo Kou, Inenaga Kiyotoshi
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Journal Title
Brain research
Volume: 1457
Pages: 70-80
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[Journal Article]2012
Author(s)
S.Shiiba, E.Sakamoto, T.Sago, H.Furuta, T.Yamamoto, Y.Tada, K.Yamaguchi, M.Yoshida, N.Harano and M.Nunomaki
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Journal Title
PEDIATRIC DENTAL JOURNAL
Volume: 22(1)
Pages: 1-5
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[Book] 永末書店2011
Author(s)
仲西修・布巻昌仁
Total Pages
62
Publisher
歯科鎮静法ハンドブック
Related Report
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