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Examination of central pain suppression in a facial cancer model

Research Project

Project/Area Number 22792005
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionKyushu Dental College

Principal Investigator

HARANO Nozomu  九州歯科大学, 歯学部, 助教 (50423976)

Co-Investigator(Renkei-kenkyūsha) ONO Kentarou  九州歯科大学, 歯学部, 准教授 (40316154)
INENAGA Kiyotoshi  九州歯科大学, 歯学部, 教授 (90131903)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords口腔顔面癌 / 癌性疼痛 / 三叉神経脊髄路核尾側亜核 / アストロサイト / ミクログリア / 顔面癌 / 三叉神経脊髄路核 / プロペントフィリン / 疼痛抑制
Research Abstract

Glial activation in the central nervous system, but not in the peripheral nervous system, mediates the enhancement of spontaneous pain and the development of allodynia and hyperalgesia at an early stage in the facial cancer model. And central glial hyperactivation, transient microglial hyperactivation and persistent astrocytic hyperactivation, contributes to the development of pain hypersensitivity but not to the maintenance of pain in this model.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2012 2011 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (4 results)

  • [Journal Article] Distinct time courses of microglial and astrocytic hyperactivation and the glial contribution to pain hypersensitivity in a facial cancer model2012

    • Author(s)
      Teppei Sago, Kentaro Ono, Nozomu Harano, et al
    • Journal Title

      Brain Research

      Volume: 1457 Pages: 70-80

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A rat pain model of facial cancer2012

    • Author(s)
      Ono K, Harano N, Inenaga K, Nakanishi O.
    • Journal Title

      Methods Mol Biol

      Volume: 851 Pages: 149-157

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Distinct time courses of microglia and astrocytic hyperactivation and the glial contribution to pain hypersensitivity in a facial cancer model2012

    • Author(s)
      Teppei Sago, Kentaro Ono, Nozomu Harano, et al
    • Journal Title

      BRAIN RESEARCH

      Volume: 1457 Pages: 70-80

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central glial activation mediates cancer-induced pain in a rat facial cancer model2011

    • Author(s)
      K. Hidaka, K. Ono, N. Harano, et al
    • Journal Title

      Neuroscience

      Volume: 180 Pages: 334-343

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanisms of cancer-induced pain

    • Author(s)
      Kentaro Ono, Nozomu Harano, et al.
    • Journal Title

      Journal of the Kyushu Dental Society

      Volume: Vol65, No.3 Pages: 60-67

    • NAID

      10029478719

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] ラット三叉神経節ニューロンにおけるエンドセリンB受容体を介した細胞内カルシウム濃度上昇2012

    • Author(s)
      山本徹, 小野堅太郎, 人見涼露, 原野望, 吉田充広, 布巻昌仁, 椎葉俊司, 稲永清敏
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本
    • Year and Date
      2012-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 口腔顔面癌領域のガン性疼痛の抑制を考える2012

    • Author(s)
      原野望
    • Organizer
      第22回九州歯科麻酔シンポジウム
    • Place of Presentation
      長崎
    • Year and Date
      2012-03-10
    • Related Report
      2011 Final Research Report
  • [Presentation] ラット三叉神経節ニューロンにおけるエンドセリンB受容体を介した細胞内カルシウム濃度上昇2012

    • Author(s)
      N.Harano, et al
    • Organizer
      日本生理学会
    • Place of Presentation
      松本市
    • Related Report
      2011 Annual Research Report
  • [Presentation] Central glial activation mediates cancer-induced pain in a rat facial cancer model2010

    • Author(s)
      N. Harano, et al
    • Organizer
      Neuroscience
    • Place of Presentation
      San Diego Convention Center
    • Related Report
      2011 Final Research Report 2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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