Development of novel treatment targeting Hedgehog signal in oral cancer
| Project/Area Number |
22792008
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Wakayama Medical University (2011-2012)
Meikai University (2010) |
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Principal Investigator |
TANAKA Akio 和歌山県立医科大学, 医学部, 学内助教 (30406392)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | Hedgehog シグナル / 口腔扁平上皮癌 / Sonic Hedgehog / Ptch1 / Gli1 / Smoothened / Hedgehogシグナル / Gli2 / 免疫組織化学的検索 |
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| Research Abstract |
In this study, we investigated the Hh signaling transduction pathway and signal inhibition in the oral squamous cell carcinoma. Immunohistochemical method showed high expression of Shh and Ptch1. Culture cells showed high expression of Shh and SMO protein. RealTime PCR showed that the expressions of Hh signaling factors were inhibited by cyclopamine. These findings suggest that the possibility of novel treatment targeting in oral cancer by Hh signal inhibition.
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Report
(4 results)
Research Products
(12 results)
