Association between central sensitization-induced pain and pain-related gene polymorphisms in patients undergoing painful oral surgery

• Project/Area Number: 22792010
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Keio University
• Principal Investigator: MURAOKA Wataru 慶應義塾大学, 医学部, 客員講師 (70317254)
• Research Collaborator: WAJIMA Kouichi 慶應義塾大学, 医学部, 専任講師 (70138105)
• Project Period (FY): 2010-04-01 – 2013-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 歯学 / 口腔外科 / 疼痛 / 中枢性感作 / ＣＯＭＴ遺伝子 / 抜歯 / 遺伝子多形 / COMT遺伝子 / 遺伝子多型

Research Abstract

In patients undergoing painful oral surgery of wisdom tooth extraction, whether central sensitization is induced were evaluated using the examination of temporal summation by repetitive thermal stimulation. We investigated the association between temporal summation and perioperative pain. The results showed that the measurement of after sensation may be able to detect central sensitization without interference from acute pain. It suggests that preoperative pain is able to predict protracted postoperative pain by examination of after sensation.

Research Products

• [Journal Article] Lack of temporal summation but distinct aftersensations to thermal stimulation in patients with combined tension-type headache and myofascial temporomandibular disorder (2012)
  • Author(s): Sato H, Saisu H, Muraoka W, Nakagawa T, Svensson P, Wajima K
  • Journal Title: J Orofac Pain Volume: 26(4) Pages: 288-95
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=Lack+of+temporal+summation+but+distinct+aftersensations+to+thermal+stimulation+in+patients+with+combined+tension-type+headache+and+myofascial+temporomandibular+disorder
  • Peer Reviewed
• [Journal Article] Lack of temporal summation but distinct aftersensations to thermal stimulation in patients with combined tension-type headache and myofascial temporomandibular disorder. (2012)
  • Author(s): Sato H, Saisu H, Muraoka W, Nakagawa T, Svensson P, Wajima K.
  • Journal Title: J Orofac Pain Volume: 26(4) Pages: 288-295
  • Peer Reviewed
• [Presentation] 口腔顔面痛疾患におけるPain Catastrophizing Scale による臨床的検討 (2013)
  • Author(s): 村岡渡, 西須大徳, 中川種昭, 和嶋 浩一
  • Organizer: 第18回日本口腔顔面痛学会学術大会
  • Place of Presentation: 大宮
  • Year and Date: 2013-07-12
• [Presentation] 外科的顎矯正手術におけるUGT2B7遺伝子多型とフェンタニル薬剤感受性の関連について (2011)
  • Author(s): 村岡渡, 西澤大輔, 長谷川準子, 笠井慎也, 和嶋浩一, 中川種昭, 福田謙一, 池田和隆
  • Organizer: 第41回日本神経精神薬理学会
  • Place of Presentation: 京王プラザホテル(東京)
  • Year and Date: 2011-10-28
• [Presentation] 口腔顔面痛学会シンポジウム「非歯原性歯痛ガイドライン」診察・検査と診断(CQ3,4,5)について (2011)
  • Author(s): 村岡渡
  • Organizer: 第16回日本口腔顔面痛学会
  • Place of Presentation: 神戸国際会議場(兵庫)(招待講演)
  • Year and Date: 2011-10-09
• [Presentation] Mini Symposium "Nonodontogenic Toothache" what are the Sources of Nonodontogenic Toothache? (2010)
  • Author(s): Muraoka W
  • Organizer: The 13th Scientific Meeting Asian Academy of Cranio Mandibular Dirsorder
  • Place of Presentation: Fukuoka
  • Year and Date: 2010-10-02
• [Presentation] Central sensitization phenomena in orofacial pain patients-assessing temporal summation upon application of heat. (2010)
  • Author(s): Sato H
  • Organizer: The 13th Scientific Meeting Asian Academy of Cranio Mandibular Dirsorder
  • Place of Presentation: Fukuoka
  • Year and Date: 2010-10-02
• [Presentation] 口腔顔面痛疾患におけるPain Catastrophizing Scaleによる臨床的検討
  • Author(s): 村岡渡、西須大徳、中川種昭、和嶋浩一
  • Organizer: 第18回日本口腔顔面痛学会学術大会
  • Place of Presentation: 大宮ソニックシティー（埼玉）
• [Patent(Industrial Property Rights)] CENTARAL SENSITIZATION DIAGNOSIS DEVICE AND METHOD FOR OPERATING SAME (2013)
  • Inventor(s): WAJIMA,Koichi; SATO,Hitoshi; SAISU,Hironori; MURAOKA,Wataru; NAKAGAWA,Taneaki; KATO, Yasunori
  • Industrial Property Rights Holder: KEIO UNIVERSITY
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-02-19
  • Overseas
• [Patent(Industrial Property Rights)] CENTARAL SENSITIZATION DIAGNOSIS DEVICE AND METHOD FOR OPERATING SAME. (2013)
  • Inventor(s): 和嶋浩一，佐藤仁，西須大徳，村岡渡，中川種昭，加藤康徳
  • Industrial Property Rights Holder: 和嶋浩一，佐藤仁，西須大徳，村岡渡，中川種昭，加藤康徳
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-02-19
  • Overseas
• [Patent(Industrial Property Rights)] 中枢感作診断装置及びその動作方法 (2012)
  • Inventor(s): 和嶋浩一, 佐藤仁, 西須大徳, 村岡渡, 中川種昭, 加藤康徳
  • Industrial Property Rights Holder: 学校法人慶應義塾
  • Industrial Property Rights Type: 特許
  • Acquisition Date: 2012-02-20
• [Patent(Industrial Property Rights)] 中枢感作診断装置及びその動作方法 (2012)
  • Inventor(s): 和嶋浩一、佐藤仁、西須大徳、村岡渡、中川種昭、加藤康徳
  • Industrial Property Rights Holder: 学校法人慶應義塾
  • Filing Date: 2012-02-20