Association between central sensitization-induced pain and pain-related gene polymorphisms in patients undergoing painful oral surgery
| Project/Area Number |
22792010
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Keio University |
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Principal Investigator |
MURAOKA Wataru 慶應義塾大学, 医学部, 客員講師 (70317254)
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| Research Collaborator |
WAJIMA Kouichi 慶應義塾大学, 医学部, 専任講師 (70138105)
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| Project Period (FY) |
2010-04-01 – 2013-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯学 / 口腔外科 / 疼痛 / 中枢性感作 / ＣＯＭＴ遺伝子 / 抜歯 / 遺伝子多形 / COMT遺伝子 / 遺伝子多型 |
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| Research Abstract |
In patients undergoing painful oral surgery of wisdom tooth extraction, whether central sensitization is induced were evaluated using the examination of temporal summation by repetitive thermal stimulation. We investigated the association between temporal summation and perioperative pain. The results showed that the measurement of after sensation may be able to detect central sensitization without interference from acute pain. It suggests that preoperative pain is able to predict protracted postoperative pain by examination of after sensation.
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Report
(4 results)
Research Products
(12 results)
