Telomerase-Specific Replication-Selective Virotherapy combined with radiation therapy for oral squamous cell carcinoma cells.

Research Project

Project/Area Number	22792013
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Surgical dentistry
Research Institution	Showa University
Principal Investigator	KURIHARA Yuji 昭和大学, 歯学部, 助教 (90514969)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	口腔癌 / ウイルス治療 / 放射線治療 / テロメラーゼ
Research Abstract	We describe the mechanistic basis for synergy of irradiation and virotherapy. This combination therapy was more effective compared with Telomelysin alone in OSCC cells. These results illustrate the potential of combining oncolytic virotherapy and ionizing radiation as a promising strategy in the management of human oral cancer.