Analysis of oral cancer growth inhibitory mechanism of molecular targeted therapy

• Project/Area Number: 22792014
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Showa University
• Principal Investigator: TAKAOKA Sayaka 昭和大学, 歯学部, 助教 (00453639)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 口腔癌 / 分子標的治療 / STAT3

Research Abstract

We describe the mechanistic basis for STAT3 inhibitor(JSI-124) that we found the efficacy for oral cancer cells. Administration of JSI-124 suppresses OSCC growth through apoptosis. Additionally, we observed that the growth of xenograft SAS tumors in nude mice was significantly blocked by the administration of JSI-124 without major adverse effects.