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Analysis of structural abnormality of whole chromosomes and novel tumor suppressor gene using mapping arrays in oral cancer

Research Project

Project/Area Number 22792017
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionTokyo Dental College

Principal Investigator

YAMAMOTO Nobuharu  東京歯科大学, 歯学部, 講師 (60385185)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords口腔がん / DNAマッピングアレイ / ヘテロ接合性消失(LOH) / 口腔癌
Research Abstract

[Purpose] We analyzed genomic copy number abnormality on all genomes in the oral squamous cell carcinoma using Affymetrix GeneChip^<(R)> Mapping 10K Array in this study and tried the identification of the new metastasis connection gene of the oral cavity squamous cell carcinoma. [Materials and Methods] We used 20 oral squamous cell carcinoma cases. We analyzed a metastasis to regional lymph node-positive case(pN(+)) 3 case and a negative case(pN(-)) 2 case by GeneChip(R) Mapping 10K Array for histopathology and detected genome copy number abnormalitywere common to a pN(+) case as comparedwith a pN(-) case, and tobefound and listed the meta(we) stasis connection gene candidates who were present in theatrical company rank. Furthermore, we inspected the mRNA manifestation situation of the candidate gene by quantitative Real-time PCR.
[Results] In the region that we were common to a pN(+) case, and a genomic copy number increased, 16 regions, region that decreased were 32 regions. We listed 75 existing candidate genes on these regions. A ZDHHC14 gene did locus in the one 6q25.3 region of the region that a copy number specifically increased for a pN(+) case. As a result of having assayed the mRNA expression level of the gene, high-frequency manifestation sthenia was found (40% of 8/20 cases). Furthermore, the mRNA manifestation sthenia was significantly found in a pN(+) case (P=0.019).
[Conclusions] These results suggested the possibility that ZDHHC14 was a new metastasis of the oral squamous cell carcinoma-related gene. As for this study, information as we exceeded imagination with the conducted genomic analysis much more was obtained till now, and the results were given as a new search method surely and this gave a presentation by foreign countries thesis and gave large result.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (52 results)

All 2012 2011 2010 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (38 results) Book (1 results)

  • [Journal Article] Clinical study of multiple primary and double cancers including oral squamous cell carcinoma2012

    • Author(s)
      Yamamoto, N., Okubo, T., Sakuma, T., Sugahara, K., Yamamoto, M., Muramatsu, K., Watanabe, A., Yakushiji, T., Nomura, T., Takano, N., Shibahara, T.
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: (in press) Issue: 4 Pages: 189-194

    • DOI

      10.1016/j.ajoms.2012.01.016

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aneurysmal bone cyst in mandible : Report of 2 cases and review of literature2012

    • Author(s)
      Sakuma, T., Yamamoto, N., Onoda, T., Sugahara, K., Yamamoto, M., Muramatsu, K., Watanabe, A., Kamio, T., Sakamoto, J., Sano, T., Matsuzaka, K., Takano, N., Shibahara, T.
    • Journal Title

      Journal of Oral and Maxilldfacial Surgery, Medicine, and Pathology

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of copy number abnormality (CNA) and loss of heterozygosity(LOH) in the whole genome using single nucleotide polymorphism (SNP) genotyping arrays in tongue squamous cell carcinoma2011

    • Author(s)
      Kuroiwa T., Yamamoto N., Onda T., Bessho H., Yakushiji T., Katakura A., Takano N., Shibahara T
    • Journal Title

      Journal of the Korean Association of Oral and Maxillofacial Surgeons

      Volume: 37 Pages: 550-555

    • NAID

      10027088647

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ステノン管原発の耳下腺扁平上皮癌の1例2011

    • Author(s)
      山本信治、小林史明、高木亮、江口淳、橋本貞光、柴原孝彦
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 57 Pages: 274-278

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of copy number abnormality (CNA) and loss of heterozygosity (LOH) in the whole genome using single nucleotide polymorphism (SNP) genotyping arrays in tongue squamous cell carcinoma2011

    • Author(s)
      Kuroiwa, T., Yamamoto, N., Onda, T., Bessho, H., Yakushiji, T., Katakura, A., Takano, N., Shibahara, T.
    • Journal Title

      Journal of the Korean Association of Oral and Maxillofacial Surgeons

      Volume: 37 Pages: 550-555

    • NAID

      10027088647

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant expression of the ZDHHC14gene in squamous cell carcinoma of the human tongue2010

    • Author(s)
      Onda T., Yamamoto N., Kuroiwa T., Katakura A., Takano N., Shibahara T
    • Journal Title

      Asian Journal of Oral and Maxillofacial Surgery

      Volume: 22 Pages: 187-192

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 副咽頭間隙に進展した巨大な多形腺腫の1例2010

    • Author(s)
      別所央城、山本信治、作間巧、橋本貞光、高野伸夫、柴原孝彦
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 56 Pages: 313-317

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 抜歯を契機に発見した上顎智歯から上顎洞に生じた動静脈奇形の1例2010

    • Author(s)
      藥師寺孝、菅原圭亮、池田千早、山本信治、柴原孝彦、笠原清弘
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 56 Pages: 600-604

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 下顎骨に発生した脈瘤性骨嚢胞の画像所見2010

    • Author(s)
      神尾崇、坂本潤一郎、和光衛、佐野司、作間巧、山本信治、柴原孝彦
    • Journal Title

      歯科学報

      Volume: 110 Pages: 472-477

    • NAID

      10029356426

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 市原市における行政主導の口腔がん検診2010

    • Author(s)
      菅原圭亮, 高橋真言, 河地誉, 池田千早, 藥師寺孝, 山本信治, 野村武史, 高野伸夫, 柴原孝彦, 片倉朗
    • Journal Title

      老年歯科医学

      Volume: 25 Pages: 340-346

    • NAID

      10030470465

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant expression of the ZDHHC14 gene in squamous cell carcinoma of the human tongue.2010

    • Author(s)
      Onda, T., Yamamoto, N., Kuroiwa, T., Katakura, A., Takano, N., Shibahara, T.
    • Journal Title

      Asian Journal of Oral and Maxillofacial Surgery

      Volume: 22 Pages: 187-192

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical study of multiple primary and double cancers including oral squamous cell carcinoma

    • Author(s)
      Yamamoto N., Okubo T., Sakuma T., Sugahara K., Yamamoto M., Muramatsu K., Watanabe A., Yakushiji T., Nomura T., Takano N., Shibahara T
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aneurysmal bone cyst in mandible : Report of 2 cases and review of literature

    • Author(s)
      Sakuma, T., Yamamoto, N., Onda, T., Sugahara, K., Yamamoto, M., Muramatsu, K., Watanabe, A., Kamio, T., Sakamoto, J., Sano, T., Matsuzaka, K., Takano, N., Shibahara, T
    • Journal Title

      Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 東京歯科大学千葉病院口腔外科における平成21年度および22年度の初診患者・全身麻酔施行患者の臨床統計2012

    • Author(s)
      逢坂竜太、折戸聡、川上真奈、恩田健志、山本信治、野村武史、山内智博、須賀賢一郎、中野洋子、高木多加志、内山健志、高野伸夫、柴原孝彦
    • Organizer
      第21回日本有病者歯科医療学会総会
    • Place of Presentation
      宇都宮市
    • Year and Date
      2012-03-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 舌扁平上皮癌における浸潤様式に関する臨床的検討-第1報: YK分類について-2012

    • Author(s)
      山本信治、逢坂竜太、菅原圭亮、藥師寺孝、野村武史、山内智博、高野伸夫、柴原孝彦、松坂賢一
    • Organizer
      第30回日本口腔腫瘍学会総会
    • Place of Presentation
      大宮市
    • Year and Date
      2012-01-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 舌扁平上皮癌における浸潤様式に関する臨床的検討-第2報: YK分類の予後不良症例について-2012

    • Author(s)
      逢坂竜太、山本信治、菅原圭亮、藥師寺孝、野村武史、山内智博、高野伸夫、柴原孝彦、松坂賢一
    • Organizer
      第30回日本口腔腫瘍学会総会
    • Place of Presentation
      大宮市
    • Year and Date
      2012-01-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 口腔扁平上皮癌の診断用分子マーカーの探索2012

    • Author(s)
      恩田健志、渡部幸央、作間巧、藥師寺孝、山本信治、野村武史、高野伸夫、柴原孝彦
    • Organizer
      第30回日本口腔腫瘍学会総会
    • Place of Presentation
      大宮市
    • Year and Date
      2012-01-26
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Low-grade dysplasiaを伴う口腔白板症の臨床統計的検討2012

    • Author(s)
      渡部幸央、野村武史、関根理予、菅原圭亮、恩田健志、藥師寺孝、山本信治、高野伸夫、柴原孝彦
    • Organizer
      第30回日本口腔腫瘍学会総会
    • Place of Presentation
      大宮市
    • Year and Date
      2012-01-26
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 健常粘膜から上皮内癌における血管形態の3次元構築画像による検討2012

    • Author(s)
      関根理予、藥師寺孝、渡部幸央、菅原圭亮、池田千早、山本信治、野村武史、高野伸夫、柴原孝彦、片倉朗、田中陽一
    • Organizer
      第30回日本口腔腫瘍学会総会
    • Place of Presentation
      大宮市
    • Year and Date
      2012-01-26
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 舌扁平上皮癌における浸潤様式に関する臨床的検討-第2報:YK分類の予後不良症例について-2012

    • Author(s)
      逢坂竜太、山本信治、菅原圭亮、藥師寺孝、野村武史、山内智博、高野伸夫、柴原孝彦、松坂賢一
    • Organizer
      第30回日本口腔腫瘍学会総会
    • Place of Presentation
      大宮市
    • Year and Date
      2012-01-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 舌扁平上皮癌における浸潤様式に関する臨床的検討-第1報:YK分類について-2012

    • Author(s)
      山本信治、逢坂竜太、菅原圭亮、藥師寺孝、野村武史、山内智博、高野伸夫、柴原孝彦、松坂賢一
    • Organizer
      第30回日本口腔腫瘍学会総会
    • Place of Presentation
      大宮市
    • Year and Date
      2012-01-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 下顎骨に発生した脈瘤性骨嚢胞の2例2011

    • Author(s)
      作間巧、恩田健志、山本信治、神尾崇、坂本潤一郎、内山健志、高野伸夫、柴原孝彦
    • Organizer
      第192回日本口腔外科学会関東地方会
    • Place of Presentation
      東京都
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Proteomics based identification of differentially expressed proteins in human oral squamous cell carcinoma2011

    • Author(s)
      Onda, T., Sakuma, T., Bessho, H., Yakushiji, T., Yamamoto, N., Nomura, T., Takano, N., Shibahara, T
    • Organizer
      第89回国際口腔外科学会
    • Place of Presentation
      サンディエゴ(チリ)
    • Year and Date
      2011-10-26
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] T1, T2舌扁平上皮癌におけるYK分類4C, 4D型に関する臨床的検討2011

    • Author(s)
      山本信治、逢坂竜太、菅原圭亮、藥師寺孝、野村武史、山内智博、高野伸夫、柴原孝彦、村松敬
    • Organizer
      第56回日本口腔外科学会総会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 蛍光光学機器を用いた悪性・前癌病変におけるSurgical marginの設定2011

    • Author(s)
      野村武史、渡部幸央、関根理予、恩田健志、藥師寺孝、山本信治、高野伸夫、柴原孝彦
    • Organizer
      第56回日本口腔外科学会総会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 角化嚢胞性歯原性腫瘍に由来する原発性下顎骨扁平上皮癌の1例2011

    • Author(s)
      吉田秀児、山本信治、山内智博、田中順一、高野伸夫、柴原孝彦
    • Organizer
      第56回日本口腔外科学会総会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 口腔扁平上皮癌の分泌タンパク質解析2011

    • Author(s)
      恩田健志、作間巧、藥師寺孝、山本信治、野村武史、高野伸夫、柴原孝彦
    • Organizer
      第56回日本口腔外科学会総会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 地域歯科医師会と共同で行ってきた口腔がん検診-千葉市での20年間の実績と将来展望-2011

    • Author(s)
      菅原圭亮、大野啓介、藥師寺孝、山本信治、野村武史、高野伸夫、柴原孝彦、片倉朗
    • Organizer
      第56回日本口腔外科学会総会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Low-grade dysplasiaを伴う口腔白板症の臨床統計的検討2011

    • Author(s)
      渡部幸央、関根理予、菅原圭亮、恩田健志、藥師寺孝、山本信治、野村武史、高野伸夫、柴原孝彦
    • Organizer
      第56回日本口腔外科学会総会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] T1,T2舌扁平上皮癌におけるYK分類4C,4D型に関する臨床的検討2011

    • Author(s)
      山本信治、逢坂竜太、菅原圭亮、藥師寺孝、野村武史、山内智博、高野伸夫、柴原孝彦、村松敬
    • Organizer
      第56回日本口腔外科学会総会
    • Place of Presentation
      大阪市
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 東京歯科大学千葉病院口腔外科当直業務における過去5年間の患者の臨床統計2011

    • Author(s)
      藤本侑子、太尾英子、折戸聡、中田江利加、井本大智、村松恭太郎、恩田健志、山本信治、野村武史、山内智博、須賀賢一郎、中野洋子、大畠仁、高木多加志、内山健志、高野伸夫、柴原孝彦
    • Organizer
      第292回東京歯科大学学会総会
    • Place of Presentation
      千葉市
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 東京歯科大学千葉病院口腔外科における平成22年度初診患者の臨床統計2011

    • Author(s)
      中田江利加、折戸聡、藤本侑子、太尾英子、川上真奈、恩田健志、山本信治、野村武史、山内智博、須賀賢一郎、中野洋子、大畠仁、高木多加志、内山健志、高野伸夫、柴原孝彦
    • Organizer
      第292回東京歯科大学学会総会
    • Place of Presentation
      千葉市
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] T1, T2舌扁平上皮癌における浸潤様式に関する臨床的検討2011

    • Author(s)
      山本信治、逢坂竜太、菅原圭亮、藥師寺孝、野村武史、山内智博、高野伸夫、柴原孝彦、村松敬
    • Organizer
      第21回日本口腔粘膜学会総会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2011-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] 健常粘膜から上皮内癌における血管形態の3次元構築画像による検討2011

    • Author(s)
      関根理予、藥師寺孝、菅原圭亮、池田千早、山本信治、野村武史、高野伸夫、柴原孝彦、片倉朗、田中陽一
    • Organizer
      第21回日本口腔粘膜学会総会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] NBI搭載拡大内視鏡による口腔粘膜の観察-正常粘膜所見-2011

    • Author(s)
      藥師寺孝、関根理予、菅原圭亮、野村武史、山本信治、高野伸夫、柴原孝彦
    • Organizer
      第21回日本口腔粘膜学会総会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] T1,T2舌扁平上皮癌における浸潤様式に関する臨床的検討2011

    • Author(s)
      山本信治、逢坂竜太、菅原圭亮、藥師寺孝、野村武史、山内智博、高野伸夫、柴原孝彦、村松敬
    • Organizer
      第21回日本口腔粘膜学会総会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 拡大内視鏡観察結果から生検を行い確定診断が得られた早期舌癌の3例2011

    • Author(s)
      加藤宏、藥師寺孝、関根理予、渡部幸央、菅原圭亮、山本信治、野村武史、高野伸夫、柴原孝彦
    • Organizer
      第191回日本口腔外科学会関東地方会
    • Place of Presentation
      横浜市
    • Year and Date
      2011-07-09
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 口腔扁平上皮癌におけるCRISP3遺伝子解析2011

    • Author(s)
      菅原圭亮、作間巧、大野啓介、河地誉、藥師寺孝、山本信治、野村武史、高野伸夫、柴原孝彦
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-06-10
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Linear array genotyping kitを用いた口腔扁平上皮癌患者のHPV検出2011

    • Author(s)
      大野啓介、菅原圭亮、河地誉、関根理予、山本信治、片倉朗、高野伸夫、柴原孝彦
    • Organizer
      第35回日本頭頸部癌学会
    • Place of Presentation
      名古屋市
    • Year and Date
      2011-06-09
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Oral squamous cell carcinoma and cultural risk in Japan2011

    • Author(s)
      Nomura, T., Kawachi, H., Sugahara, K., Ikeda, C., Yakushiji, T., Yamamoto, N., Takano, N., Shibahara, T
    • Organizer
      第89回IADR学会総会
    • Place of Presentation
      サンディエゴ(アメリカ)
    • Year and Date
      2011-03-17
    • Related Report
      2011 Final Research Report
  • [Presentation] NBIシステム搭載拡大内視鏡により発見した早期浸潤扁平上皮癌の5例2011

    • Author(s)
      関根理予、藥師寺孝、菅原圭亮、池田千早、山本信治、野村武史、片倉朗、高野伸夫、柴原孝彦
    • Organizer
      第29回日本口腔腫瘍学会総会
    • Place of Presentation
      熊本市
    • Year and Date
      2011-01-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 口腔粘膜疾患における内視鏡的診断の試み-NBIシステム搭載拡大内視鏡による口腔粘膜の観察-2011

    • Author(s)
      藥師寺孝、関根理予、菅原圭亮、別所央城、恩田健志、池田千早、山本信治、野村武史、高野伸夫、柴原孝彦、片倉朗
    • Organizer
      第29回日本口腔腫瘍学会総会
    • Place of Presentation
      熊本市
    • Year and Date
      2011-01-27
    • Related Report
      2011 Final Research Report
  • [Presentation] Verification of gene polymorphism in oral squamous cell carcinoma2010

    • Author(s)
      Kawachi, H., Sugahara, K., Ikeda, C., Yakushiji, T., Yamamoto, N., Nomura, T., Takano, N., Shibahara, T., Katakura, A
    • Organizer
      第9回アジア口腔顎顔面外科学会総会
    • Place of Presentation
      クアラルンプール(マレーシア)
    • Year and Date
      2010-10-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Over expression of zinc finger, DHHC-type containing14gene located on chromosome 6q25.3 in human tongue squamous cellcarcinoma2010

    • Author(s)
      Onda, T., Yamamoto, N., Uchiyama, T., Takano, N., Shibahara, T
    • Organizer
      第9回アジア口腔顎顔面外科学会総会
    • Place of Presentation
      クアラルンプール(マレーシア)
    • Year and Date
      2010-10-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 口腔癌の多発癌・重複癌に関する臨床的検討2010

    • Author(s)
      山本信治、河地誉、菅原圭亮、池田千早、藥師寺孝、野村武史、高野伸夫、柴原孝彦
    • Organizer
      第55回日本口腔外科学会総会
    • Place of Presentation
      千葉市
    • Year and Date
      2010-10-16
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 台湾における口腔がんの臨床統計2010

    • Author(s)
      柯文昌、河地誉、菅原圭亮、作間巧、池田千早、藥師寺孝、山本信治、高野伸夫、柴原孝彦
    • Organizer
      第55回日本口腔外科学会総会
    • Place of Presentation
      千葉市
    • Year and Date
      2010-10-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 口腔扁平上皮癌患者のCRISP3遺伝子解析2010

    • Author(s)
      菅原圭亮、作間巧、池田千早、大野啓介、河地誉、藥師寺孝、山本信治、高野伸夫、柴原孝彦
    • Organizer
      第55回日本口腔外科学会総会
    • Place of Presentation
      千葉市
    • Year and Date
      2010-10-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 下顎骨に生じた脈瘤性骨嚢胞と線維性骨異形成症が併発した1例2010

    • Author(s)
      作間巧、山本信治、神尾崇、坂本潤一郎、松坂賢一、佐野司、柴原孝彦
    • Organizer
      第44回日本口腔科学会関東地方部会
    • Place of Presentation
      浦安市
    • Year and Date
      2010-09-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 口底部に発生した舌神経由来神経鞘腫の1例2010

    • Author(s)
      岩本昌士、山本信治、松坂賢一、柴原孝彦
    • Organizer
      第189回日本口腔外科学会関東地方会
    • Place of Presentation
      栃木県
    • Year and Date
      2010-06-19
    • Related Report
      2011 Final Research Report
  • [Presentation] 東京歯科大学千葉病院における口腔癌の多発癌・重複癌に関する臨床的検討2010

    • Author(s)
      大久保剛、山本信治、菅原圭亮、池田千早、藥師寺孝、野村武史、高野伸夫、大森泰、石井康裕、柴原孝彦
    • Organizer
      第289回東京歯科大学学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2010-05-09
    • Related Report
      2011 Final Research Report
  • [Presentation] 台湾における口腔扁平上皮癌患者のCRISP3遺伝子解析2010

    • Author(s)
      柯文昌、菅原圭亮、作間巧、池田千早、藥師寺孝、山本信治、野村武史、高野伸夫、柴原孝彦
    • Organizer
      第289回東京歯科大学学会総会
    • Place of Presentation
      東京都
    • Year and Date
      2010-05-09
    • Related Report
      2011 Final Research Report
  • [Book] 口腔外科ハンドマニュアル'10-口腔がんの予防-2010

    • Author(s)
      野村武史、山本信治
    • Publisher
      クインテッセンス出版
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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