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Mutation in 10 Gene are the Genetic Factor for Nonsyndromic Cleft Lip and/or Cleft Palate

Research Project

Project/Area Number 22792018
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionTokyo Dental College

Principal Investigator

WATANABE Akira  東京歯科大学, 歯学部, 助教 (50408324)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords口唇裂・口蓋裂 / 候補遺伝子 / SNP / 変異解析 / 相関解析 / TDT検定 / 連鎖不平衡 / DNA / TDT
Research Abstract

We performed mutation analysis of 10 genes(RYK(3q22)、EPHB2(1p36.1-35)、EPHB3(3q28-27)、DLX3(17q23)、TBX10(11q13.1)、TGF-B3(14q24)、PAX9(14q12-q13)、CLPTM1(19q13.2)、PVRL1(11q23)、TBX22(Xq21.1)), case-control study, TDT(transmission disequilibrium test) in the parents with the patients with cleft lip and/or cleft palate. We found a gene associated with the appearance of disease of cleft lip and/or cleft palate.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (5 results)

  • [Journal Article] No evidence of association between 8q24 and susceptibility to nonsyndromic cleft lip with or without palate in Japanese population2011

    • Author(s)
      Hikida M, Tsuda M, Watanabe A, Kinoshita A, Akita S, Hirano A, Uchiyama T, Yoshiura
    • Journal Title

      Cleft Palate Craniofac J

    • Related Report
      2011 Final Research Report
  • [Journal Article] No evidence of association between 8q24 and susceptibility to nonsyndromic cleft lip with or without palate in Japanese population2011

    • Author(s)
      Hikida M, Tsuda M, Watanabe A
    • Journal Title

      Cleft Palate Craniofac J

      Volume: (掲截確定) Issue: 6 Pages: 714-717

    • DOI

      10.1597/10-242

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] RYK遺伝子変異は非症候性の口唇裂・口蓋裂発症における遺伝要因の一つである2010

    • Author(s)
      渡邊章, 秋田定伯, 夏目長門, 中野洋子, 内山健志, 吉浦孝一郎
    • Journal Title

      日本口蓋裂学会雑誌

      Volume: 35巻1号 Pages: 9-17

    • NAID

      10029088703

    • Related Report
      2011 Final Research Report
  • [Journal Article] RYK遺伝子変異は非症候性の口唇裂・口蓋裂発症における遺伝要因の一つである2010

    • Author(s)
      渡邊章
    • Journal Title

      日本口蓋裂学会雑誌

      Volume: 35 Pages: 9-17

    • NAID

      10029088703

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Current problems associated with orthognathic surgery for secondary cleft palate skeletal deformity2011

    • Author(s)
      Akira Watanabe
    • Organizer
      The 50th Congress of the Korean Association of Maxillofacial Plastic and Reconstructive Surgeons
    • Place of Presentation
      韓国(水原市)(招待講演)
    • Year and Date
      2011-11-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 口唇裂・口蓋裂発症に関与の報告がある10遺伝子の解析2011

    • Author(s)
      渡邊章, 内山健志, 夏目長門, 引田正宣, 中野洋子, 須賀賢一郎, 大畠仁, 高野伸夫, 柴原孝彦
    • Organizer
      日本口腔外科学会雑誌
    • Related Report
      2011 Final Research Report
  • [Presentation] 日本人唇顎口蓋裂の関連遺伝子8q24領域の解析2011

    • Author(s)
      引田正宣, 津田雅由, 渡邊章, 平野明喜, 吉浦孝一郎, 高野伸夫, 内山健志
    • Organizer
      日本口蓋裂学会雑誌
    • Related Report
      2011 Final Research Report
  • [Presentation] 口唇裂・口蓋裂発症に関与するとされている10遺伝子の解析2010

    • Author(s)
      渡邊章
    • Organizer
      日本口蓋裂学会
    • Place of Presentation
      東京都
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口唇裂・口蓋裂の分子遺伝学研究これまでの研究成果とこれからの原因追究口唇裂・口蓋裂発症に関与するとされている10遺伝子の解析

    • Author(s)
      渡邊章
    • Organizer
      日本口蓋裂学会
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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