| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Research Abstract |
A nude mouse was injected an oral squamous cell carcinoma cell line : SCCKN at the subcutaneously back and made a transplant tumor. The transplant tumor was treated by the gene therapy of pFasL or pFasL/E3D1 gene. The pFasL or pFasL/E3D1 gene was injected every week. The all mice of control group and/or treated of pFasL gene group were dead of 49^<th> days. But, the survival rate of mice with treated by pFasL/E3D1 was 87% at 49^<th> days. It was confirmed that the dosage of pFasL/E3D1 controls the increase of tumor, and there is a survival benefit in a transplant tumor.
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