Availability of measurement of salivary alpha-amylase activity for evaluation of surgical stimuli and postoperative pain

• Project/Area Number: 22792020
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Surgical dentistry
• Research Institution: Nihon University
• Principal Investigator: HIROSE Noriya 日本大学, 医学部, 助手 (80366608)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
• Keywords: 疼痛評価 / 唾液アミラーゼ活性 / 疾痛評価

Research Abstract

In this study, salivary alpha-amylase activity(sAA) which indicate of sympathetic activity was significantly induced after tracheal intubation and skin incision under general anesthesia. In contrast, perioperative and postoperative sAA values did not associate with sAA, VAS(visual analogue scale) and analgesic agent usage during 48 hours after operation. These results suggest that measurement of sAA might be a method for evaluation of noxious stimuli under general anesthesia, however, it is probably difficult to assess postoperative pain.