Analysis of promoter of human BRAK/CXCL14, a tumor suppressor
Project/Area Number |
22792023
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Surgical dentistry
|
Research Institution | Kanagawa Dental College |
Principal Investigator |
KOMORI Reika 神奈川歯科大学, 歯学部, 助教 (40555281)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 癌 / BRAK/CXCL14 / プロモーター / 転写因子 / 腫瘍抑制因子 |
Research Abstract |
BRAK/CXCL14 is a chemokine that is absent from or expressed at very low levels in head and neck squamous cell carcinoma. We set to this gene as molecular target therapy. In order to study the regulatory mechanisms governing the expression of this gene, we determined the promoter motifs of the expression of this gene. The results of that, TATA-like sequence, TATTAA was essential for stimulating the expression of the gene and the AP-1 binding sequence and tandem GC Box3, 4 were necessary for stimulating the expression of the gene in human squamous epithelial cells.
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Report
(3 results)
Research Products
(6 results)