| Project/Area Number |
22792032
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Hokkaido University |
|---|
Principal Investigator |
TANIGUCHI Yumi 北海道大学, 北海道大学病院, 医員 (80543503)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 乳歯歯根吸収 / 破骨細胞 / Treg細胞 / T細胞 / 炎症性サイトカイン / 歯学 / 歯根膜細胞 / 免疫担当 |
|---|
| Research Abstract |
Normal root resorption of deciduous teeth is physiological process and caused by osteoclasts. However, non-physiological root resorption of deciduous teeth is sometimes occurred for several reasons. The mechanism of non-physiological resorption is unknown. In this study, I searched for the cause of non-physiological root resorption in the interaction of osteoclast precursor cells and T cells. As a result, it was found that T cells acted directly on osteoclast precursor cells and suppressed differentiation into osteoclasts.
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