Mechanism of non-physiological root resorption of deciduous teeth

• Project/Area Number: 22792032
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Hokkaido University
• Principal Investigator: TANIGUCHI Yumi 北海道大学, 北海道大学病院, 医員 (80543503)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 乳歯歯根吸収 / 破骨細胞 / Treg細胞 / T細胞 / 炎症性サイトカイン / 歯学 / 歯根膜細胞 / 免疫担当

Research Abstract

Normal root resorption of deciduous teeth is physiological process and caused by osteoclasts. However, non-physiological root resorption of deciduous teeth is sometimes occurred for several reasons. The mechanism of non-physiological resorption is unknown. In this study, I searched for the cause of non-physiological root resorption in the interaction of osteoclast precursor cells and T cells. As a result, it was found that T cells acted directly on osteoclast precursor cells and suppressed differentiation into osteoclasts.

Research Products

• [Journal Article] (2011) Platinum nanoparticles suppress osteoclastogenesis through scavenging of ROS productions in RAW264. 7 cells (2011)
  • Author(s): Mayumi Nomura, Yoshitaka Yoshimura, Takashi Kikuiri, Tomokazu Hasegawa, Yumi Taniguchi, Yoshiaki Deyama, Ken-ichi Koshiro, Hidehiko Sano Kuniaki Suzuki and Nobuo Inoue
  • Journal Title: Journal of Pharmacological Sciences Volume: 117 Pages: 243-252
  • Peer Reviewed
• [Journal Article] (2011) Effect of the release from mechanical stress on osteoclastogenesis in RAW264. 7 cells (2011)
  • Author(s): Kenjiro Shibata, Yoshitaka Yoshimura, Takashi Kikuiri, Tomokazu Hasegawa, Yumi Taniguchi, Yoshiaki Deyama Kuniaki Suzuki and Junichiro Iida
  • Journal Title: International Journal of Molecular Medicine Volume: 28(1) Pages: 73-79
  • Peer Reviewed
• [Journal Article] Effect of the release from mechanical stress on osteoclastogenesis in RAW 264. 7 cells (2011)
  • Author(s): Shibata K, Yoshimura Y, Kikuiri T, Hasegawa T, Taniguchi Y, Deyama Y, Suzuki K, Iida J.
  • Journal Title: Int J Molecular Medicin Volume: 28 Pages: 73-79
  • DOI: 10.3892/ijmm.2011.675
  • Peer Reviewed
• [Journal Article] Platinum Nanoparticles Suppress Osteoclastogenesis Through Scavenging of Reactive Oxygen Species Produced in RAW264.7 Cells (2011)
  • Author(s): Nomura M, Yoshimura Y, Kikuiri T, Hasegawa T, Taniguchi Y, Deyama Y, Koshiro K, Sano H, Suzuki K, Inoue N.
  • Journal Title: Journal of Pharmacological Sciences Volume: 117 Issue: 4 Pages: 243-252
  • DOI: 10.1254/jphs.11099FP
  • NAID: 10030453660
  • ISSN: 1347-8613, 1347-8648
  • Peer Reviewed
• [Journal Article] Effect of the release from mechanical stress on osteoclastogenesis in RAW264.7 cells (2011)
  • Author(s): KENJIRO SHIBATA
  • Journal Title: International Journal of Molecular Medicine Volume: (印刷中)
  • Peer Reviewed