| Project/Area Number |
22792047
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯科矯正学 / オートファジー / 鼻口蓋管 / 口蓋の発生 / 上皮接着因子 / 組織学 |
|---|
| Research Abstract |
In this study, our objective is to identify the role of Autophagy at the nasopalatine duct. First, we clarified the morphological change of nasopalatine ducts with tissue sections of mice from embryonic stage to postnatal stage. And we revealed the morphological distinctions of the nasopalatine ducts between control and Atg5 knockout mice, too. Next, we elucidated the genes which change the expression levels when the nasopalatine ducts develop and differentiate. From these results, we suggest that Autophagy is specifically expressed in the nasopalatine ducts, and it has important roles in development and differentiation.
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