The mechanism of the myofunctional recovery using RNA interference aiming at the treatment of the skeletal muscle disorder

• Project/Area Number: 22792055
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: KAWAI Nobuhiko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (40437588)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 筋ジストロフィー / マイオスタチン / RNA干渉 / 筋電図 / 咀嚼筋

Research Abstract

The purpose of this study was to evaluate the efficiency of a myostatin-targeting siRNA(Mst-siRNA) for the recovery of muscle functions using muscular dystrophy model mice. The injection of the Mst-siRNA into the masseter muscle induced an increase in muscle mass and a muscle activity. These results suggested that the administration of Mst-siRNA might be a candidate for the treatment of muscular atrophy.

Research Products

• [Journal Article] Adaptation of rat jaw muscle fibers in postnatal development with a different food consistency : an immunohistochemical and electromyographic study (2010)
  • Author(s): Kawai N, Sano R, Korfage JAM, Nakamura S, Kinouchi N, Kawakami E, Tanne K, Langenbach GEJ, Tanaka E.
  • Journal Title: Journal of Anatomy Volume: 216 Issue: 6 Pages: 717-723
  • DOI: 10.1111/j.1469-7580.2010.01235.x
  • Peer Reviewed
• [Journal Article] Adaptation of rat jaw muscle fibers in postnatal development with a different food consistency : an immunohistochemical and electromyographic study. (2010)
  • Author(s): Nobuhiko Kawai, et al
  • Journal Title: Journal of Anatomy Volume: 216 Pages: 717-723
  • Peer Reviewed
• [Presentation] 筋ジストロフィーモデルマウスにおけるRNA干渉を用いた咀嚼筋機能の回復 (2011)
  • Author(s): 川合暢彦, 川上恵美, 中村彩花, 木内奈央, 田中栄二
  • Organizer: 第47回日本顎口腔機能学会学術大会,兵庫医療大学神戸キャンパス
  • Place of Presentation: 神戸
  • Year and Date: 2011-10-22
• [Presentation] 筋ジストロフィーモデルマウスにおけるRNA干渉を用いた咀嚼筋機能の回復 (2011)
  • Author(s): 川合暢彦
  • Organizer: 日本顎口腔機能学会
  • Place of Presentation: 兵庫医療大学(兵庫県)
  • Year and Date: 2011-10-22
• [Presentation] Influences of the mastication on the development of jaw muscles in rats. International Joint Symposium on Oral Science : The University of Tokushima, Universitas Gadjah Mada (2010)
  • Author(s): Kawai N.
  • Organizer: Niigata University, The Patra Bali
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2010-12-17
• [Presentation] Influences of the mastication on the development of jaw muscles in rats (2010)
  • Author(s): Nobuhiko Kawai
  • Organizer: International Joint Symposium on Oral Science
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2010-12-17
• [Presentation] 特殊加工コラーゲンを単体としたマイオスタチンsiRNA投与による骨格筋量調節法の研究 (2010)
  • Author(s): 川上恵実, 木内奈央, 足立太郎, 中村彩花, 川合暢彦, 田中栄二, 野地澄晴
  • Organizer: 第69回日本矯正歯科学会大会,パシフィコ横浜
  • Place of Presentation: 横浜市
  • Year and Date: 2010-09-27