The mechanism of the myofunctional recovery using RNA interference aiming at the treatment of the skeletal muscle disorder
Project/Area Number |
22792055
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Orthodontic/Pediatric dentistry
|
Research Institution | The University of Tokushima |
Principal Investigator |
KAWAI Nobuhiko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (40437588)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 筋ジストロフィー / マイオスタチン / RNA干渉 / 筋電図 / 咀嚼筋 |
Research Abstract |
The purpose of this study was to evaluate the efficiency of a myostatin-targeting siRNA(Mst-siRNA) for the recovery of muscle functions using muscular dystrophy model mice. The injection of the Mst-siRNA into the masseter muscle induced an increase in muscle mass and a muscle activity. These results suggested that the administration of Mst-siRNA might be a candidate for the treatment of muscular atrophy.
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Report
(3 results)
Research Products
(7 results)