The elucidation of thealveolar bone bone resorption mechanism with tooth eruption

• Project/Area Number: 22792063
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Kyushu Dental College
• Principal Investigator: MORIKAWA Kazumasa 九州歯科大学, 歯学部, 助教 (70514686)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 歯学 / 骨吸収 / 破骨細胞 / 細胞接着 / 萌出 / 歯の萌出 / 歯槽骨骨吸収 / 歯槽骨 / イノシトール1,4,5-三リン酸受容体 / Adenophostin A

Research Abstract

Inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) are Ca2+channels that localize to intracellular Ca2+stores. Our data strongly suggest IP3R type III may be related to regulation of an actin cytoskeleton in podosomes, actin-rich adhesion structures in osteoclasts and may be associated with the alveolar bone bone resorption.

Research Products

• [Journal Article] Mineral trioxide aggregate solution inhibits osteoclast differentiation through the maintenance of osteoprotegerin expression in osteoblasts (2011)
  • Author(s): Hashiguchi D, Fukushima H, Nakamura M, Morikawa K, Yasuda H, Udagawa N, Maki K, Jimi E
  • Journal Title: J Biomed Mater Res A Volume: 96 Pages: 358-64
  • Peer Reviewed
• [Journal Article] Mineral trioxide aggregate inhibits osteoclastic bone resorption (2011)
  • Author(s): Hashiguchi D, Fukushima H, Yasuda H, Masuda W, Tomikawa M, Morikawa K, Maki K, Jimi E
  • Journal Title: J Dent Res Volume: 90 Pages: 912-7
  • Peer Reviewed
• [Presentation] MTA セメントは破骨細胞の分化と骨吸収機能を抑制する (2010)
  • Author(s): 橋口大輔、福島秀文、森川和政、藤田優子、自見英治郎、牧 憲司
  • Organizer: 九州歯科学会
  • Place of Presentation: 北九州
  • Year and Date: 2010-05-23
• [Presentation] MTA セメントは破骨細胞の分化の抑制と機能抑制により骨吸収を抑制する (2010)
  • Author(s): 橋口大輔、福島秀文、森川和政、自見英治郎、牧 憲司
  • Organizer: 日本小児歯科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-05-20
• [Presentation] 歯の萌出に伴う歯槽骨骨吸収メカニズムの解明-特に細胞接着について (2010)
  • Author(s): 森川和政、柏谷雅信、梅津哲夫、橋口大輔、佐伯 桂、牧 憲司
  • Organizer: 日本小児歯科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-05-19
• [Presentation] 歯の萌出に伴う歯槽骨骨吸収メカニズムの解明-特に細胞接着について(第2報)- (2010)
  • Author(s): 森川和政、柏谷雅信、梅津哲夫、橋口大輔、佐伯桂、牧憲司
  • Organizer: 日本小児歯科学会
  • Place of Presentation: 名古屋