The role for the stress protein in regulation of development of themandibular condylar cartilage by mechanical stress
Project/Area Number |
22792064
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Orthodontic/Pediatric dentistry
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Research Institution | Kyushu Dental College |
Principal Investigator |
FUJITA Yuko 九州歯科大学, 歯学部, 助教 (90514670)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | 小児歯科 / 下顎頭 / 軟骨内骨化 / HO-1 / 軟骨細胞 / マウス / ヘムオキシゲナーゼ1 |
Research Abstract |
This study investigated the localization and expression of heme oxygenase (HO)-1, type II and X collagen (Col10 and 2) and matrix metalloproteinase (MMP)-13 proteins in mouse mandibular condylar cartilage and mouse tibial cartilage. C57BL/6J mice aged 1, 7, 14, 21 and 49 days were subjected to using immunohistochemistry. This study demonstrated that HO-1 is the protein which expresses specifically to early stages of the development, in particular under hypoxia environment in chondrocytes. These findings suggest that HO-1 is involved in the process of the endochondral ossification from a blood vessel invasion in hypertrophic chondrocytes and acts as a regulatory factor in the early stages of the development of condylar cartilage.
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Report
(4 results)
Research Products
(23 results)