| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Research Abstract |
This study investigated the localization and expression of heme oxygenase (HO)-1, type II and X collagen (Col10 and 2) and matrix metalloproteinase (MMP)-13 proteins in mouse mandibular condylar cartilage and mouse tibial cartilage. C57BL/6J mice aged 1, 7, 14, 21 and 49 days were subjected to using immunohistochemistry. This study demonstrated that HO-1 is the protein which expresses specifically to early stages of the development, in particular under hypoxia environment in chondrocytes. These findings suggest that HO-1 is involved in the process of the endochondral ossification from a blood vessel invasion in hypertrophic chondrocytes and acts as a regulatory factor in the early stages of the development of condylar cartilage.
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