| Project/Area Number |
22792065
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
OKAYAMA Miki 北海道医療大学, 歯学部, 助教 (30382500)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | メカニカルストレス / 歯根膜 / 歯の移動 / 歯根吸収 / ヒト歯根膜 / ＬＰＡ受容体 / ＤＮＡマクロアレイ / 骨関連遺伝子 / DNAチップ |
|---|
| Research Abstract |
ID1 (Inhibitor of DNA binding 1), EGR1 (Early growth response 1), SGK1 (Regulator of G-protein signaling 2) and DUSP1 (Dual specificity phosphatase 1) were upregulated in 2 hours by 7G-loading in human PDL cells. U0126, MEK inhibitor diminished up-regulation and phosphorylation of these genes. Thus, the phosphorylation of ERK had crucial rule in genes induced by mechanical stress. It was also suggested that the mechanical stress controlled remodeling of periodontal tissues and tooth root resorption through extracellular matrix degradation.
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