The elucidation of the new osteoclast differentiation factor revealed from the pressure zone of periodontal ligament cells during tooth movement

• Project/Area Number: 22792072
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Tsurumi University
• Principal Investigator: ARAI Chihiro 鶴見大学, 歯学部, 助教 (10460221)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 歯科矯正学 / 歯の移動 / Heat Shock Protein / Heat shock protein / 破骨細胞 / 歯骨細胞

Research Abstract

Gene expression of the pressure zone of periodontal ligament cells(PDL) during orthodontic tooth movement in vivo was observed. Heat shock protein A1A(HSPA1A) in the pressure zone of the PDL was higher during 6 h of tooth movement than that in the control group. These results strongly suggest that expression of HSPA1A in the PDL during the early stage of tooth movement is a critical factor for tissue reaction.

Research Products

• [Journal Article] Human periodontal ligament fibroblasts are the optimal source for induced pluripotent stem cells (2012)
  • Author(s): Nomura Y, Arai C, et al
  • Journal Title: Histochem Cell Biol Volume: (In press)
  • Peer Reviewed
• [Journal Article] Mechanism of active eruption of molars in adolescent rats (2011)
  • Author(s): Oikawa T, Nomura Y, Arai C, Noda K, Hanada N and Nakamura Y
  • Journal Title: Eur J Orthod Volume: 33(3) Pages: 221-227
• [Journal Article] Immunocompetent cells and cytokine expression in the rat periodontal ligament at the initial stage of orthodontic tooth movement (2011)
  • Author(s): Baba S, Kuroda N, Arai C, Nakamura Y, Sato T
  • Journal Title: Arch Oral Biol Volume: 56(5) Pages: 466-473
• [Journal Article] Fiber system degradation, and periostin and connective tissue growth factor level reduction, in the periodontal ligament of teeth in the absence of masticatory load (2011)
  • Author(s): Choi J W, Arai C, Ishikawa M, Shimoda S, Nakamura Y
  • Journal Title: J Periodontal Res Volume: 46(5) Pages: 513-521
• [Journal Article] Root resorption after experimental tooth movement using superelastic forces in the rat (2010)
  • Author(s): Noda K, Arai C, Nakamura Y
  • Journal Title: Eur J Orthod Volume: 32(6) Pages: 681-7
• [Journal Article] HSPA1A is upregulated in periodontal ligament at early stageof tooth movement in rats (2010)
  • Author(s): Arai C・Nomura Y・Ishikawa M・Noda K Choi J W・Yashiro Y・Hanada N・NakamuraY
  • Journal Title: Histochem Cell Biol Volume: 134(4) Pages: 337-343
• [Journal Article] HSPA1A is upregulated in periodontal ligament at early stage of tooth movement in rats. (2010)
  • Author(s): Arai Chihiro, et al
  • Journal Title: Histochem Cell Biol. Volume: 134 Pages: 337-343
  • Peer Reviewed
• [Journal Article] Root resorption after experimental tooth movement using superelastic forces in the rat. (2010)
  • Author(s): Noda K, Arai C, Nakamura Y
  • Journal Title: Eur J Orthod. Volume: 32 Pages: 681-7
  • Peer Reviewed
• [Journal Article] Mechanism of active eruption of molars in adolescent rats. (2010)
  • Author(s): Oikawa T, Nomura Y, Arai C, et al.
  • Journal Title: Eur J Orthod Volume: (In press)
  • Peer Reviewed
• [Journal Article] Immunocompetent cells and cytokine expression in the rat periodontal ligament at the initial stage of orthodontic tooth movement. (2010)
  • Author(s): Baba S, Kuroda N, Arai C, Nakamura Y, Sato T.
  • Journal Title: Arch Oral Biol. Volume: (In press)
  • Peer Reviewed
• [Presentation] ヒト歯根膜線維芽細胞からのiPS細胞の樹立 (2011)
  • Author(s): 石川美佐緒、新井千博, 他
  • Organizer: 日本矯正科歯科学会大会
  • Place of Presentation: 愛知県名古屋国際会議場
• [Presentation] 圧迫側歯根膜に発現する熱ショックタンパク質について (2010)
  • Author(s): 新井千博、野村義明、野田晃司、石川美佐緒、崔齊原、八城祐一、花田信弘、中村芳樹
  • Organizer: 第69回日本矯正歯科学会学術大会
  • Place of Presentation: 横浜
• [Presentation] HSP70 is Highly Expressed in PDL During the Tooth Movement (2010)
  • Author(s): C. Arai, Y. Nomura, M. Ishikawa, J-W. Choi, K. Noda, S. Imai, N. Hanada, Y. Nakamura
  • Organizer: 88^<th> General Session & Exhibition of the IADR
  • Place of Presentation: Barcelona
• [Presentation] 圧迫側歯根膜に発現する熱ショックタンパク質について (2010)
  • Author(s): 新井千博, 他
  • Organizer: 第69回日本矯正歯科学会大会
  • Place of Presentation: 横浜