The function of miRNA in postnatal development of the muscle of mastication and gustro of the third molar deficit model mouse

• Project/Area Number: 22792073
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Tsurumi University
• Principal Investigator: TOMOHIRO Tadafumi 鶴見大学, 歯学部, 臨床助手 (30460231)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: ELマウス / 第三臼歯欠損 / シナプス形成 / miRNA / ミオシン重鎖 / 咬筋 / miR-1 / miR-133 / Real-time PCR / 生後発達過程 / EL/Seaマウス / 第三臼歯欠失 / 側頭筋 / アセチルコリン受容体 / サブユニット / mRNA / Real time PCR

Research Abstract

The results using mutant mice with deficiency of the 3^<rd> molars suggest that normal occlusal activity is essential for synaptogenesis in the masseter muscle. The results using wild type mice suggest that miRNA-1 regulates the expression of myosin heavy chains in the masseter muscle.

Research Products

• [Journal Article] Effect of third molar absence on development of masticatory muscles in EL mice (2010)
  • Author(s): NARIYAMA, M., KOTA, Y., TASHIMA, I., TOMOHIRO, T., YAMANE, A. and ASADA, Y
  • Journal Title: Pediatric Dent. J Volume: 20(2) Pages: 122-129
  • NAID: 10027485798
• [Journal Article] Effect of third molar absence on development of masticatory muscles in EL mice (2010)
  • Author(s): NARIYAMA, M., KOTA, Y., TASHIMA, I., TOMOHIRO, T., YAMANE, A., ASADA, Y.
  • Journal Title: Pediatric Dent.J. Volume: 20 Pages: 122-129
  • NAID: 10027485798
  • Peer Reviewed
• [Presentation] マウス第三臼歯欠如が咀嚼筋の発達過程に及ぼす影響 (2010)
  • Author(s): 成山明具美、古宇田ゆき、田島格、友廣忠文、山根明、朝田芳信
  • Organizer: 第48回小児歯科学会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Effects of lack of cclusal activity on masticatory myogenesis (2010)
  • Author(s): NARIYAMA, M., KOTA, Y., YAMANE, A., TOMOHIRO, T. and ASADA, Y
  • Organizer: 88th General Session & Exhibition of the IADR. Centre de Convencions Internacional Barcelona
  • Place of Presentation: Barcelona, Spain
• [Presentation] Effects of lack of cclusal activity on masticatory myogenesis (2010)
  • Author(s): NARIYAMA, M., KOTA, Y., YAMANE, A., TOMOHIRO, T., ASADA, Y.
  • Organizer: 88th General Session & Exhibition of the IADR
  • Place of Presentation: Centre de Convencions Internacional Barcelona, Barcelona, Spain