Elucidation of molecular mechanism in aplastic of cranial base synchondrosis through the hedgehog signaling pathway.

Research Project

Project/Area Number	22792074
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Orthodontic/Pediatric dentistry
Research Institution	Matsumoto Dental University
Principal Investigator	TAKANAGA Ochiai 松本歯科大学, 歯学部, 口腔病理学講座助教 (20410417)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	歯科矯正学 / 軟骨 / 発生・分化 / シグナル伝達 / 分子機構
Research Abstract	We examine that chondrocyte influence due to the abnormal Indian hedgehog pathway which was important to chondrocyte differentiation. We elucidated a production decrease in heparan sulfate proteoglycan which was an extra-celler matrix by the abnormality of the Indian hedgehog pathway. Furthermore, we elucidated that heparan sulfate proteoglycan was combined with an Indian hedgehog protein. These results suggest that heparan sulfate proteoglycan might be controlled in the cartilage differentiation through Indian hedgehog pathway.

Report

(4 results)