| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
The experiment was performed for understanding of the mechanism of soft palate development. We demonstrated a unique pattern of periostin expression during soft palate development, which was closely related to that of collagen type I(Col I) in palatine aponeurosis. Furthermore, organ culture analysis showed that exogenous transforming growth factor-β(TGF-b) induced the expression of both periostin and Col I. TGF-b signaling appears to be one of the mediators of Col I and periostin expression in the formation of functional structures during soft palate development.
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