Analysis of the mechanism of FGF-2 enhancement induced by extracellular calcium in cementoblasts
Project/Area Number |
22792079
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Periodontal dentistry
|
Research Institution | Tohoku University |
Principal Investigator |
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | セメント芽細胞 / 細胞外カルシウム / PMA / FGF-2 / プロテインキナーゼC / カルシウム |
Research Abstract |
We found that extracellular calcium increases fibroblast growth factor-2 expression levels via a cAMP/Protein kinase A dependent pathway in cementoblasts. We also found that Phorbol 12-myristate 13-acetate (PMA), the potent stimulator of Protein kinase C increases FGF-2 expression in cementoblasts. These indicate the presence of different pathways for FGF-2 enhancement in cementoblasts.
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Report
(3 results)
Research Products
(6 results)