Mechanism of Th17 regulation based on TGF beta in progression of periodontits

• Project/Area Number: 22792080
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KOBAYASHI Hiroaki 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (50396967)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 歯周病 / IL-17A / IL-17F / 侵襲性歯周炎 / TGF beta / 歯周炎 / Anandamide

Research Abstract

Concentration of IL-17F and IL-17A in serum from aggressive periodontitis is lower than that of healthy control. Concentration of IL-17F in Aggressive periodontitis is lower than that of chronic periodontitis. 5patients who have high IL-17F level in serum, have localized periodontitis lesion, and their bone loss levels were not severe as compared to other aggressive patients.

Research Products

• [Journal Article] Modulation of Wnt5a expression by periodontopathic bactreia (2012)
  • Author(s): Hiromi Nanbara, Nawarat Wara-aswapati, Toshiyuki Nagasawa, Yasuhiro Yoshida, Reiko Yashiro, Yukiko Bando, Hiroaki Kobayashi, Janjura Khongcharoensuk, Doosadee Hormdee, Waranuch Pitiphat, Jason A. Boch, Yuichi Izumi.
  • Journal Title: Plos ONE Volume: 7(4)
• [Journal Article] Modulation of Wnt5a expression by periodontopathic bactreia (2012)
  • Author(s): Nanbara H, et al
  • Journal Title: Plos ONE Volume: 7
  • Peer Reviewed
• [Journal Article] Current and future periodontal tissue engineering (2011)
  • Author(s): Izumi Yuichi, Aoki Akira, Yamada Yuichi, Kobayashi Hiroaki, Iwata Takanori, Akizuki Tatsuya, Suda Tomonari, Nakamura Sayaka, Wara-Aswapati Nawarat, Ueda Minoru, Ishikawa I.
  • Journal Title: Periodontol 2000 Volume: 56(1) Pages: 166-87
• [Journal Article] Gene expression analysis of resident macrophages in lipopolysac charide-stimulated rat molar pulps (2011)
  • Author(s): Chokechanachaisakul U, et al
  • Journal Title: Journal of Endodontology Volume: 37 Issue: 6 Pages: 1258-1263
  • DOI: 10.1016/j.joen.2011.03.010
  • Peer Reviewed
• [Presentation] A role of cannabinoid system in periodontal tissue (2012)
  • Author(s): Kobayashi H, Haruta C, Izumi Y.
  • Organizer: 4th Academy of Advanced Applied Science in Oral Medicine
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2012-01-21
• [Presentation] Wnt5a expression by Porphyromonas gingivalis LPS via NF-κB and STAT1 (2011)
  • Author(s): Nanbara H, Kobayashi H, Izumi Y, et al
  • Organizer: The 10th World Congress on Inflammation
  • Place of Presentation: Paris, France
• [Presentation] ヒト単球系細胞THP-1における歯周病原細菌刺激によるWnt5a遺伝子発現について (2011)
  • Author(s): 南原弘美、和泉雄一, ら
  • Organizer: 第54回日本歯周病学会春季学術大会
  • Place of Presentation: 博多
• [Presentation] Induction of Wnt5a in THP-1 cells by periodontopathic bacteria (2010)
  • Author(s): Nanbara H, Kobayashi H
  • Organizer: 第88回International Association of Dental Research
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-07-16
• [Presentation] Induction of Wnt5a in THP-1 cells by periodontopathic bacteria (2010)
  • Author(s): Nanbara H, Kobayashi H, Izumi Y, et al
  • Organizer: 88^<th> International and American Association for Dental Research
  • Place of Presentation: Barcelona, Spain
• [Presentation] P. gingivalis LPS induce Wnt5a via NF-κB and STAT1 signaling pathway (2010)
  • Author(s): Nanbara H, Kobayashi H, Izumi Y, et al
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸
• [Presentation] Functions of PI3K and MAPK on Wnt5a expression in THP-1 (2010)
  • Author(s): Nanbara H, Kobayashi H, Izumi Y, et al
  • Organizer: 58^<th> JapaneseAssociation for Dental Research
  • Place of Presentation: Kokura, Japan