The analysis and application for periodontal treatment of FcRn which is tha passive IgG transporter in epithelial cells

• Project/Area Number: 22792085
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Periodontal dentistry
• Research Institution: Hiroshima University
• Principal Investigator: OUHARA Kazuhisa 広島大学, 医歯薬保健学研究院, 助教 (80550425)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 歯肉上皮細胞 / FcRn / 歯周炎 / Ig / 能動輸送 / IgG / 抗体

Research Abstract

The neonatal Fc receptor (FcRn) for IgG expressed in intestinalepithelium has been shown to be responsible for IgG transport. In this study, we determined the expression of FcRn in gingival epithelium and the function of FcRn. Our results suggested that FcRn expressed in GEC may contribute to the recycling of IgG in the oral cavity.

Research Products

• [Journal Article] Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice (2013)
  • Author(s): Furusho H, Miyauchi M, Hyogo H, Inubushi T, Ao M, OuharaK, Hisatune J, Kurihara H, Sugai M, Hayes CN, Nakahara T, Aikata H, Takahashi S, Chayama K, Takata T
  • Journal Title: J Gastroenterol
  • Peer Reviewed
• [Journal Article] Irsogladine maleate regulates the inflammatory related genes in human gingival epithelial cells stimulated by Aggregatibacter actinomycetemcomitans. (2013)
  • Author(s): Miyagawa T
  • Journal Title: Int Immunopharmacol Volume: 15 Issue: 2 Pages: 340-347
  • DOI: 10.1016/j.intimp.2012.12.011
  • Peer Reviewed
• [Journal Article] Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice. (2013)
  • Author(s): Furusho H
  • Journal Title: J Gastroenterol. Volume: Jan 11
  • Peer Reviewed
• [Journal Article] Antimicrobial peptide LL37 promotes vascular endothelial growth factor-A expression in human periodontal ligament cells. (2013)
  • Author(s): Kittaka M
  • Journal Title: J Periodontal Res Volume: Apr;48(2) Issue: 2 Pages: 228-34
  • DOI: 10.1111/j.1600-0765.2012.01524.x
  • Peer Reviewed
• [Journal Article] Expression levels of novel cytokine IL-32 in periodontitis and its role in the suppression of IL-8 production by human gingival fibroblasts stimulated with Porphyromonas gingivalis (2012)
  • Author(s): Ouhara K, Kawai T, Silva MJ, Fujita T, Hayashida K, Karimbux NY, Kajiya M, Shiba H, Kawaguchi H, Kurihara H
  • Journal Title: J Oral Microbiol Volume: 4 Issue: 1 Pages: 14832-14832
  • DOI: 10.3402/jom.v4i0.14832
  • Peer Reviewed
• [Journal Article] Smad2 is involved in the apoptosis of murine gingival junctional epithelium associated with inhibition of Bcl-2. (2012)
  • Author(s): Fujita T.
  • Journal Title: Arch Oral Biol. Volume: Nov;57(11) Issue: 11 Pages: 1567-73
  • DOI: 10.1016/j.archoralbio.2012.08.011
  • Peer Reviewed
• [Journal Article] Irsogladine maleate regulates epithelial barrier function in tumor necrosis factor-α-stimulated human gingival epithelial cells (2012)
  • Author(s): 藤田剛, 他10名
  • Journal Title: Journal of Periodontal Eesearch Volume: Feb;47(1) Issue: 1 Pages: 55-61
  • DOI: 10.1111/j.1600-0765.2011.01404.x
  • Peer Reviewed
• [Journal Article] The antimicrobial peptide LL37 induces the migration of human pulp cells : a possible adjunct for regenerative endodontics. (2010)
  • Author(s): 加治屋幹人, 他9名
  • Journal Title: Journal of Endodontology Volume: Jun;36(6) Pages: 1009-1013
  • Peer Reviewed
• [Journal Article] Irsogladine maleate regulates neutrophil migration and E-cadherin expression ingingival epithelium stimulated by Aggregatibacter actinomycetemcomitans. (2010)
  • Author(s): 藤田剛, 他11名
  • Journal Title: Biochemical Pharmacology Volume: May15;79(10) Pages: 1496-505
  • Peer Reviewed
• [Presentation] 嚢胞様根尖病巣由来滲出液中のサイトカイン産生量プロファイリング (2012)
  • Author(s): 應原 一久
  • Organizer: 第5回日本口腔検査学会総会・学術大会
  • Place of Presentation: 東京
• [Presentation] ヒト歯肉上皮細胞における Porphyromonas gingivalis 刺激時の microRNA 発現の網羅的解析 (2012)
  • Author(s): 東京
  • Organizer: 日本歯周病学会 2012 秋季学術大会
  • Place of Presentation: つくば市
• [Presentation] 広島大学病院歯周診療科・口臭外来における口臭検査 －平成22－23年度受診患者の傾向－ (2012)
  • Author(s): 應原 一久
  • Organizer: 日本歯周病学会 第7回 中国地区臨床研修会
  • Place of Presentation: 松江市
• [Presentation] 嚢胞様根尖病巣由来滲出液中のサイトカイン産生量プロファイリング (2012)
  • Author(s): 應原 一久
  • Organizer: 第５回日本口腔検査学会総会・学術大会
  • Place of Presentation: 東京
• [Presentation] ヒト歯肉上皮細胞におけるPorphyromonas gingivalis刺激時のmicroRNA発現の網羅的解析 (2012)
  • Author(s): 應原 一久
  • Organizer: 日本歯周病学会 2012秋季学術大会
  • Place of Presentation: つくば市
• [Presentation] 嚢胞様根尖病巣由来滲出液中のサイトカイン産生量プロファイリング (2012)
  • Author(s): 應原 一久
  • Organizer: 第51回広島県歯科医学会・第96回広島大学歯学会
  • Place of Presentation: 広島市
• [Presentation] 嚢胞様根尖病巣に対する選択的抗菌薬療法 (2012)
  • Author(s): 應原 一久
  • Organizer: 第22回日本歯科医学会総会
  • Place of Presentation: 大阪市
• [Presentation] 根尖病変を「宿主－寄生体相互作用」の概念から捉えた新しい検査・治療法の確立 (2012)
  • Author(s): 應原 一久
  • Organizer: 日本歯科保存学会 2012秋季学術大会（第137回）
  • Place of Presentation: 広島市
  • Invited
• [Presentation] ヒト末梢血単核球におけるIL-32の破骨細胞への影響 (2011)
  • Author(s): 應原一久
  • Organizer: 第134回日本歯科保存学会学術大会
  • Place of Presentation: 浦安市
  • Year and Date: 2011-06-09
• [Presentation] The-break-of-immunetolerance to oral-commensal-bacteria leads to periodontal bone loss in mouse (2010)
  • Author(s): 應原一久
  • Organizer: International Assiciation of Dental Research
  • Place of Presentation: Balcerona, Spain
  • Year and Date: 2010-07-17
• [Presentation] 炎症性サイトカインIL-32の歯周組織における発現およびPBMCに対する作用 (2010)
  • Author(s): 應原一久
  • Organizer: 第53回日本歯周病学会学術大会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-05-15