| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Since gingival epithelial cell layer functions as a mechanical barrier, the permeability of epithelial cell layer indicates the defensive ability against invasion of periodontal pathogens. E-cadherin and claudin-1 are key molecules to regulate permeability of epithelium. Irsogladine maleate(IM) is a medication for gastric ulcer and also regulates chemokine secretion and E-cadherin expression in gingival epithelium stimulated by Aggregatibacter actinomycetemcomitans in vivo and in vitro studies. In this study, we have further investigated the effects of IM on barrier functions of gingival epithelial cells in inflammatory condition. TNF-α induced the disruption of claudin-1 and E-cadherin and IM recovered the disruption in human gingival epithelial cell. These results suggest that IM recovers the TNF-α-induced disruption of gingival epithelial barrier by regulating E-cadherin and claudin-1.
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